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Implanted device helps patients with central sleep apnea

Date:
September 23, 2013
Source:
Ohio State University Wexner Medical Center
Summary:
A small implant being studied for the treatment of central sleep apnea is showing significant promise in patients.

A small implant being studied for the treatment of central sleep apnea is showing significant promise, according to study results presented by Dr. William Abraham, director of the Division of Cardiovascular Medicine at The Ohio State University Wexner Medical Center, during today's Late Breaking Clinical Trials session of the Heart Failure Society of America's Annual Scientific Meeting.

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"Central sleep apnea affects more than a third of heart failure patients and is known to make the condition worse," Abraham said. "Unfortunately, we don't have good treatments available for this type of apnea. Currently, positive airway pressure devices are used, but many patients don't tolerate it well."

Unlike the more common obstructive sleep apnea, in which the airway gets blocked during sleep and causes pauses in breathing, central sleep apnea is more dangerous because the brain's signals to tell the body to breathe get interrupted.

"One of the concerning features of central sleep apnea is that these patients don't fit the usual profile of obstructive sleep apnea," said Dr. Rami Khayat, a sleep medicine expert and director of Ohio State's sleep heart program. "They generally don't snore, so they're tougher to diagnose, and the symptoms of sleepiness and fatigue overlap with symptoms associated with heart failure."

Abraham and other cardiovascular researchers at 11centers around the world tested the feasibility, safety and efficacy of a new transvenous phrenic nerve stimulator made by Respicardia Inc. The device resembles a pacemaker in that it delivers a regular signal to stimulate the diaphragm to breathe during sleep.

In the pilot study, 47 patients were implanted with the device and evaluated for six months. The implant was placed below the collar bone and a transvenous stimulator lead was positioned near the phrenic nerve. After a one-month healing period, the device was turned on and programmed to the patient's sleep habits.

Researchers saw significant results, including a 56 percent reduction in overall apnea events per hour and more than 80 percent reduction in central sleep apnea events.

"The device normalized breathing during sleep, it reduced apnea episodes and, in association with that, we saw improvements in sleepiness symptoms and patients' quality of life," Abraham said. "We also noted a reduction in blood pressure in patients with hypertension."

Now researchers are comparing the device to current medical therapy for central sleep apnea in a larger randomized, controlled clinical trial. Ohio State's Wexner Medical Center is again the first in the United States to enroll patients in this research. Once study participants receive the implant, half will have the device turned on soon after surgery, while the control group will wait six months to have their device turned on. Up to 25 centers are participating in this larger randomized trial. Patients will be followed up to five years.

"If these initial findings bear out in the larger studies, an implantable device could be a good option for central sleep apnea patients who cannot tolerate positive airway pressure therapy," Khayat said.

For a video to accompany this article, please see: http://medicalcenter.osu.edu/mediaroom/releases/Pages/Sleep-Apnea-Implant.aspx


Story Source:

The above story is based on materials provided by Ohio State University Wexner Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Ohio State University Wexner Medical Center. "Implanted device helps patients with central sleep apnea." ScienceDaily. ScienceDaily, 23 September 2013. <www.sciencedaily.com/releases/2013/09/130923175743.htm>.
Ohio State University Wexner Medical Center. (2013, September 23). Implanted device helps patients with central sleep apnea. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/09/130923175743.htm
Ohio State University Wexner Medical Center. "Implanted device helps patients with central sleep apnea." ScienceDaily. www.sciencedaily.com/releases/2013/09/130923175743.htm (accessed October 25, 2014).

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