Featured Research

from universities, journals, and other organizations

Model developed for studying tissue pattern formation during embryonic development

Date:
September 25, 2013
Source:
Syracuse University
Summary:
A team of scientists is working to develop a model for studying tissue -- specifically how it organizes into organs and layers during embryonic development. Their findings may have major implications for the study of tissue pattern formation and malformation.

Experimental and simulation data from Manning's experiment, in which two "droplets" of tissue join together, in a fluid-like manner, to form a single tissue
Credit: Syracuse University

A team of scientists, including M. Lisa Manning, assistant professor of physics in Syracuse University's College of Arts and Sciences, has developed a model for studying tissue -- specifically how it organizes into organs and layers during embryonic development.

Related Articles


Their findings are the subject of a Sept. 25th article in the journal Interface (Royal Society Publishing, 2013) and may have major implications for the study of tissue pattern formation and malformation.

Central to their work was the question of whether embryonic tissue behaves more like a solid or a liquid -- and why.

"We found that embryonic tissue was viscoelastic, meaning that it behaved like a liquid, if you pushed on it slowly, but like a solid, if you pushed on it quickly," says Manning, who co-wrote the article with Eva-Maria Schoetz, assistant professor of biology and physics at the University of California, San Diego; and Marcos Lanio and Jared Talbot, both researchers in Princeton University's Lewis-Sigler Institute for Integrative Genomics. "A mixture of cornstarch and water also behaves that way."

Manning and her team found that viscoelasticity was the result of "glassy dynamics" in cells, caused by overcrowding. They discovered that cells within embryonic tissue were packed so tightly that they rarely moved -- and when they did so, they expended considerable energy to squeeze past their neighbors.

She compares this behavior to riding on a subway. "If you're on a subway train that's not very crowded, it's easy to move toward the exit and get off the train," says Manning, an expert in theoretical soft condensed matter and biological physics. "But as more people get on the train, it takes longer to pick your way past them and exit. Sometimes, if the train is jam-packed, you miss your stop completely because you can't move at all."

Experimental and simulation data from Manning's experiment, in which two "droplets" of tissue join together, in a fluid-like manner, to form a single tissue.

Using state-of-the-art imaging and image analysis techniques, Manning and her team saw that each cell was crowded by what she calls a "cage of neighbors." A simple active-matter model, which they created, has enabled them to reproduce data and make predictions about how certain changes and mutations affect embryonic development.

"This is exciting because if cells slow down or generate more sticky molecules, the tissue can turn into a solid," says Manning, adding that such alterations can trigger malformations or congenital disease. "Our results provide a framework for understanding these changes."

Manning's work is rooted in that of another Princeton scientist, the late Malcolm Steinberg, who suggested more than 50 years ago that different types of embryonic tissue behave like immiscible liquids, such as oil and water. "[This liquid-like behavior] helps tissue separate into layers and form structures, including organs," says Manning, who joined SU's faculty in 2011, after serving as a postdoctoral fellow in the Princeton Center for Theoretical Science. "This type of work is fun because it involves knowledge from lots of disciplines, from soft-matter physics and materials science to cell and developmental biology."


Story Source:

The above story is based on materials provided by Syracuse University. The original article was written by Rob Enslin. Note: Materials may be edited for content and length.


Journal Reference:

  1. E.-M. Schotz, M. Lanio, J. A. Talbot, M. L. Manning. Glassy dynamics in three-dimensional embryonic tissues. Journal of The Royal Society Interface, 2013; 10 (89): 20130726 DOI: 10.1098/rsif.2013.0726

Cite This Page:

Syracuse University. "Model developed for studying tissue pattern formation during embryonic development." ScienceDaily. ScienceDaily, 25 September 2013. <www.sciencedaily.com/releases/2013/09/130925152141.htm>.
Syracuse University. (2013, September 25). Model developed for studying tissue pattern formation during embryonic development. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2013/09/130925152141.htm
Syracuse University. "Model developed for studying tissue pattern formation during embryonic development." ScienceDaily. www.sciencedaily.com/releases/2013/09/130925152141.htm (accessed November 25, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, November 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Cambodian Capital's Only Working Elephant to Retire in Jungle

Cambodian Capital's Only Working Elephant to Retire in Jungle

AFP (Nov. 25, 2014) Phnom Penh's only working elephant was blessed by a crowd of chanting Buddhist monks Tuesday as she prepared for a life of comfortable jungle retirement after three decades of giving rides to tourists. Duration: 00:36 Video provided by AFP
Powered by NewsLook.com
Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Stray Dog Follows Adventure Racing Team for 6-Day Endurance Race

Buzz60 (Nov. 24, 2014) A Swedish Adventure racing team travels to try and win a world title, but comes home with something way better: a stray dog that joined the team for much of the grueling 430-mile race. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins