Featured Research

from universities, journals, and other organizations

Model developed for studying tissue pattern formation during embryonic development

Date:
September 25, 2013
Source:
Syracuse University
Summary:
A team of scientists is working to develop a model for studying tissue -- specifically how it organizes into organs and layers during embryonic development. Their findings may have major implications for the study of tissue pattern formation and malformation.

Experimental and simulation data from Manning's experiment, in which two "droplets" of tissue join together, in a fluid-like manner, to form a single tissue
Credit: Syracuse University

A team of scientists, including M. Lisa Manning, assistant professor of physics in Syracuse University's College of Arts and Sciences, has developed a model for studying tissue -- specifically how it organizes into organs and layers during embryonic development.

Their findings are the subject of a Sept. 25th article in the journal Interface (Royal Society Publishing, 2013) and may have major implications for the study of tissue pattern formation and malformation.

Central to their work was the question of whether embryonic tissue behaves more like a solid or a liquid -- and why.

"We found that embryonic tissue was viscoelastic, meaning that it behaved like a liquid, if you pushed on it slowly, but like a solid, if you pushed on it quickly," says Manning, who co-wrote the article with Eva-Maria Schoetz, assistant professor of biology and physics at the University of California, San Diego; and Marcos Lanio and Jared Talbot, both researchers in Princeton University's Lewis-Sigler Institute for Integrative Genomics. "A mixture of cornstarch and water also behaves that way."

Manning and her team found that viscoelasticity was the result of "glassy dynamics" in cells, caused by overcrowding. They discovered that cells within embryonic tissue were packed so tightly that they rarely moved -- and when they did so, they expended considerable energy to squeeze past their neighbors.

She compares this behavior to riding on a subway. "If you're on a subway train that's not very crowded, it's easy to move toward the exit and get off the train," says Manning, an expert in theoretical soft condensed matter and biological physics. "But as more people get on the train, it takes longer to pick your way past them and exit. Sometimes, if the train is jam-packed, you miss your stop completely because you can't move at all."

Experimental and simulation data from Manning's experiment, in which two "droplets" of tissue join together, in a fluid-like manner, to form a single tissue.

Using state-of-the-art imaging and image analysis techniques, Manning and her team saw that each cell was crowded by what she calls a "cage of neighbors." A simple active-matter model, which they created, has enabled them to reproduce data and make predictions about how certain changes and mutations affect embryonic development.

"This is exciting because if cells slow down or generate more sticky molecules, the tissue can turn into a solid," says Manning, adding that such alterations can trigger malformations or congenital disease. "Our results provide a framework for understanding these changes."

Manning's work is rooted in that of another Princeton scientist, the late Malcolm Steinberg, who suggested more than 50 years ago that different types of embryonic tissue behave like immiscible liquids, such as oil and water. "[This liquid-like behavior] helps tissue separate into layers and form structures, including organs," says Manning, who joined SU's faculty in 2011, after serving as a postdoctoral fellow in the Princeton Center for Theoretical Science. "This type of work is fun because it involves knowledge from lots of disciplines, from soft-matter physics and materials science to cell and developmental biology."


Story Source:

The above story is based on materials provided by Syracuse University. The original article was written by Rob Enslin. Note: Materials may be edited for content and length.


Journal Reference:

  1. E.-M. Schotz, M. Lanio, J. A. Talbot, M. L. Manning. Glassy dynamics in three-dimensional embryonic tissues. Journal of The Royal Society Interface, 2013; 10 (89): 20130726 DOI: 10.1098/rsif.2013.0726

Cite This Page:

Syracuse University. "Model developed for studying tissue pattern formation during embryonic development." ScienceDaily. ScienceDaily, 25 September 2013. <www.sciencedaily.com/releases/2013/09/130925152141.htm>.
Syracuse University. (2013, September 25). Model developed for studying tissue pattern formation during embryonic development. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/09/130925152141.htm
Syracuse University. "Model developed for studying tissue pattern formation during embryonic development." ScienceDaily. www.sciencedaily.com/releases/2013/09/130925152141.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Adorable Video of Baby Rhino and Lamb Friend Playing

Adorable Video of Baby Rhino and Lamb Friend Playing

Buzz60 (Oct. 20, 2014) Gertjie the Rhino and Lammie the Lamb are teaching the world about animal conservation and friendship. TC Newman (@PurpleTCNewman) has the adorable video! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins