Featured Research

from universities, journals, and other organizations

New theory in neuroscience: common mechanisms in Fragile X and Down Syndrome

Date:
October 2, 2013
Source:
Ulsan National Institute of Science and Technology (UNIST)
Summary:
A new common mechanism in Fragile X and Down Syndrome has been identified by scientists.

A new common mechanism in Fragile X and Down syndrome has been identified by scientists at Ulsan National Institute of Science and Technology (UNIST), Korea and published in the world leading science journal, Trends in Neurosciences (Cell Press).

Related Articles


Emerging evidence shows that the regulation of local protein synthesis in dendritic spines plays a crucial role in controlling synaptic morphogenesis and synaptic efficacy. However, scientist do not yet understand how local protein synthesis regulates dendritic spine morphology, a process that is important for learning and memory.

The research team led by Prof. Kyung-Tai Min from UNIST presented evidence that pathways controlled by DSCR1 and FMRP, genes implicated in two of the most common genetic causes of intellectual disabilities -- DS and FXS converge to regulate spine morphogenesis, local protein synthesis, and neurotransmission.

Min's research team highlighted the previous research work published in The EMBO Journal by Prof. Min, showing that some of the proteins altered in Fragile X and Down syndrome are common molecular triggers of intellectual disability in both disorders, DS and FXS.

They reviewed other genes encoded by chromosome 21 that may regulate dendritic spine morphogenesis and contribute to intellectual disabilities by acting through pathways involving FMRP and DSCR1.

The research work provided an important stepping stone in understanding the multiple roles of DSCR1 in neurons and in identifying a molecule that is closely linked to intellectual disability for both syndromes.

"We will continuously investigate whether reducing FMRP in DS mouse model or elevating DSCR1 in FMRP knockout mice could restore synaptic plasticity, dendritic spine morphogenesis, and local protein synthesis will further advance our understanding of both diseases," said Prof. Min, presenting future research plan.

"Further elucidation of the large functional protein-inter-action network that regulates local protein synthesis, spine morphogenesis, and synaptic transmission may also shed light on overlapping molecular pathways that cause intellectual disabilities in different disorders," added Prof. Min.


Story Source:

The above story is based on materials provided by Ulsan National Institute of Science and Technology (UNIST). Note: Materials may be edited for content and length.


Journal Reference:

  1. Karen T. Chang, Hyunah Ro, Wei Wang, Kyung-Tai Min. Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends in Neurosciences, 2013; DOI: 10.1016/j.tins.2013.08.007

Cite This Page:

Ulsan National Institute of Science and Technology (UNIST). "New theory in neuroscience: common mechanisms in Fragile X and Down Syndrome." ScienceDaily. ScienceDaily, 2 October 2013. <www.sciencedaily.com/releases/2013/10/131002102311.htm>.
Ulsan National Institute of Science and Technology (UNIST). (2013, October 2). New theory in neuroscience: common mechanisms in Fragile X and Down Syndrome. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2013/10/131002102311.htm
Ulsan National Institute of Science and Technology (UNIST). "New theory in neuroscience: common mechanisms in Fragile X and Down Syndrome." ScienceDaily. www.sciencedaily.com/releases/2013/10/131002102311.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins