Featured Research

from universities, journals, and other organizations

Bug vs. Bug: Benign C. Difficile strains keep fatal strains at bay

Date:
October 2, 2013
Source:
American Society for Microbiology
Summary:
In a recent study, two different strains of non-toxigenic Clostridium difficile provided protection against both historic and epidemic C. difficile strains.

In a recent study, two different strains of non-toxigenic Clostridium difficile provided protection against both historic and epidemic C. difficile strains. The research was conducted by researchers at Hines VA Hospital and is published ahead of print in the journal Antimicrobial Agents and Chemotherapy.

Studies show colonization with a non-disease-causing strain of C. difficile can prevent infection by the more dangerous strains. Patients who are not colonized by benign strains may risk become infected by the harmful strains. The harmless strains occupy the same niches in the intestine that the infective strains would take if the harmless strains weren't there.

In order to determine which strains provided protection researchers first treated the hamsters with an oral antibiotic to clear their systems, then colonized with one of two strains (M3 or T7) of non-toxigenic C. difficile. The hamsters were then challenged with a colonizing dose of one of two toxigenic strains (BI1 or BI6) representing both historical and current epidemic C. difficile.

All of the hamsters colonized with either non-toxigenic strain were able to prevent infection with the historic, fatal BI1 strain. Additionally, all of the hamsters colonized with M3 were able to prevent co-infection by BI6. However, "despite 100 percent colonization with the T7 non-toxigenic strain, five of ten hamsters became co-colonized with the toxigenic strain BI6 following challenge, and four of these died," says Johnson. Overall, M3 provided better protection against the fatal strains tested.

"If the findings in the hamster model of C. difficile infection can be replicated in humans, then we may have a new means of protecting susceptible, high-risk patients -- notably hospitalized patients treated with antibiotics -- or preventing relapsing disease in patients who have recovered from treatment for C. difficile," says Stuart Johnson, an author of the study. Around 25 percent of first-time patients have a recurrence of the infection.

Improvements still are needed, but the hamster study suggests that they can be achieved. "Further analysis of the phase II clinical trial will be needed to help validate the findings in this study showing protection of virulent epidemic BI-associated infections with non-toxigenic C. difficile," says Johnson.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gerding et Al. Non-toxigenic Clostridium difficile vs BI/NAP1/027. Antimicrobial Agents and Chemotherapy, October 2013

Cite This Page:

American Society for Microbiology. "Bug vs. Bug: Benign C. Difficile strains keep fatal strains at bay." ScienceDaily. ScienceDaily, 2 October 2013. <www.sciencedaily.com/releases/2013/10/131002185718.htm>.
American Society for Microbiology. (2013, October 2). Bug vs. Bug: Benign C. Difficile strains keep fatal strains at bay. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2013/10/131002185718.htm
American Society for Microbiology. "Bug vs. Bug: Benign C. Difficile strains keep fatal strains at bay." ScienceDaily. www.sciencedaily.com/releases/2013/10/131002185718.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins