Featured Research

from universities, journals, and other organizations

Obesity suppresses cellular process critical to kidney health

Date:
October 3, 2013
Source:
American Society of Nephrology (ASN)
Summary:
Unlike in normal-weight mice with kidney disease, a degradation process called autophagy is suppressed in obese mice with kidney disease. This suppression leads to kidney cell damage. In obese people the same with kidney disease, suppressed autophagy.

Obesity suppresses an important cellular process that prevents kidney cell damage, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). The findings suggest that restoring the process could protect the kidney health of obese individuals.

Obesity increases a chronic kidney disease patient’s risk of developing kidney failure, but the mechanism underlying this connection has remained unclear.

Kosuke Yamahara, Takashi Uzu, MD, PhD (Shiga University of Medical Science, in Japan), and their colleagues suspected that decreased functioning of a process called autophagy might play a role. Autophagy is a degradation system within cells that removes damaged proteins and other defective cellular components, and autophagy insufficiency is common in obese individuals.

The researchers found that in normal-weight mice with kidney disease, autophagy was active in kidney cells. However, in obese mice with kidney disease, autophagy was suppressed and kidney cells became damaged. Normal-weight mice with kidney disease and defective autophagy (due to a gene deletion) also experienced kidney cell damage.

The investigators also discovered that a potent suppressor of autophagy (called mTOR) was hyperactivated in the kidneys of obese mice, and treatment with an mTOR inhibitor ameliorated autophagy insufficiency. Furthermore, both mTOR hyperactivation and autophagy suppression were observed in kidney specimens from obese patients with kidney disease.

“Obesity suppresses autophagy via an abnormal activation of nutrition sensing signals in the kidney,” said Yamahara. “Our results suggest that restoring the kidney-protective action of autophagy may improve the kidney health of obese patients.”

In an accompanying editorial, Ken Inoki, PhD (University of Michigan) stated that “the results of this study provide an important pathomechanism underlying obesity-associated renal… cell damage.”


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. K. Yamahara, S. Kume, D. Koya, Y. Tanaka, Y. Morita, M. Chin-Kanasaki, H. Araki, K. Isshiki, S.-i. Araki, M. Haneda, T. Matsusaka, A. Kashiwagi, H. Maegawa, T. Uzu. Obesity-Mediated Autophagy Insufficiency Exacerbates Proteinuria-induced Tubulointerstitial Lesions. Journal of the American Society of Nephrology, 2013; DOI: 10.1681/ASN.2012111080

Cite This Page:

American Society of Nephrology (ASN). "Obesity suppresses cellular process critical to kidney health." ScienceDaily. ScienceDaily, 3 October 2013. <www.sciencedaily.com/releases/2013/10/131003204946.htm>.
American Society of Nephrology (ASN). (2013, October 3). Obesity suppresses cellular process critical to kidney health. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/10/131003204946.htm
American Society of Nephrology (ASN). "Obesity suppresses cellular process critical to kidney health." ScienceDaily. www.sciencedaily.com/releases/2013/10/131003204946.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins