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Sparing the body, breast cancer treatment via nipple injection

Date:
October 4, 2013
Source:
Journal of Visualized Experiments (JOVE)
Summary:
A new technique for breast cancer treatment and prevention has been proposed by researchers - injection of therapeutics via the nipple. The procedure, demonstrated on mice, offers direct access to the most common origin of breast cancer, the milk ducts, and could be used to offer cancer therapy that spares healthy regions of the body.

On October 4, JoVE, the Journal of Visualized Experiments, will publish a new technique for breast cancer treatment and prevention—injection of therapeutics via the nipple. The procedure, demonstrated on mice, offers direct access to the most common origin of breast cancer, the milk ducts, and could be used to offer cancer therapy that spares healthy regions of the body.

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“Local delivery of therapeutic agents into the breast, through intra-nipple injection, could diminish the side effects typically observed with systemic chemotherapy—where the toxic drugs pass through all of the tissues of the body,” said Dr. Silva Krause, one of the researchers behind the experiment, “It also prevents drug breakdown by the liver, for example, which can rapidly reduce effective drug levels.”

According to Silva, she and her colleagues have already begun experimentation in applying the method. “The authors have utilized this technique to inject a new nanoparticle-based therapeutic that inhibits a specific gene that drives breast cancer formation,” said Silva, “This targeted treatment was shown to prevent cancer progression in mice that spontaneously develop mammary tumors, [and] is currently in review in Science Translational Medicine.”

In order to better communicate their procedure, Silva and her colleagues decided to publish with JoVE. “Because the reader can actually watch the process and see how reagents, instruments, and animals are physically handled over time, the likelihood of reproducing this method in their own labs is greatly enhanced,” Silva said. “We believe this will help spread this new technical capability to many labs who are carrying out breast cancer research.”


Story Source:

The above story is based on materials provided by Journal of Visualized Experiments (JOVE). Note: Materials may be edited for content and length.


Cite This Page:

Journal of Visualized Experiments (JOVE). "Sparing the body, breast cancer treatment via nipple injection." ScienceDaily. ScienceDaily, 4 October 2013. <www.sciencedaily.com/releases/2013/10/131004104756.htm>.
Journal of Visualized Experiments (JOVE). (2013, October 4). Sparing the body, breast cancer treatment via nipple injection. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/10/131004104756.htm
Journal of Visualized Experiments (JOVE). "Sparing the body, breast cancer treatment via nipple injection." ScienceDaily. www.sciencedaily.com/releases/2013/10/131004104756.htm (accessed October 25, 2014).

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