Featured Research

from universities, journals, and other organizations

Leptin may explain link between abdominal obesity, cardiovascular disease

Date:
October 7, 2013
Source:
Ume universitet
Summary:
High levels of adipose tissue hormone leptin in the blood reduces blood vessels’ ability to dilate, and also affects blood clotting, all of which increase the risk of heart attack and stroke.

High levels of adipose tissue hormone leptin in the blood reduces blood vessels' ability to dilate, and also affects blood clotting, all of which increase the risk of heart attack and stroke. These are some of the results that Manuel Gonzalez shows in his thesis he defended at Ume University in Sweden on 27 September.

Related Articles


Numerous population studies have shown that overweight people, especially those with abdominal obesity, have a higher risk of coronary artery disease and myocardial infarction. The underlying mechanisms are not fully understood and the role of adipose tissue hormone leptin, which increases proportionally with increasing body mass index, BMI, has shown contradictory results.

Manuel Gonzalez demonstrates in his thesis that high levels of leptin in the blood is related to a reduced ability of blood vessels to dilate, which is an early sign of atherosclerosis. High leptin levels also affect blood clotting. These factors are characteristic of so-called endothelial dysfunction and carry an increased risk of heart attack and stroke.

To investigate the linkage closer, Manuel Gonzalez also conducted an experimental study where he gave leptin by injection into the bloodstream of healthy young men. The function of blood vessel endothelium was examined by one of the world's most precise techniques called "strain-gauge forearm pletysmography." The study results confirmed that leptin administration affects the blood vessels ability to dilate.

"These findings are of great importance for the understanding of the factors linking cardiovascular disease to obesity and will hopefully stimulate further studies in this exciting area of research," says Manuel Gonzalez.

Manuel Gonzalez is a physician and specialist in cardiology at Norrlands University Hospital, as well as a PhD student at the Department of Public Health and Clinical Medicine. He grew up in Madrid, Spain, where he also received his medical degree.


Story Source:

The above story is based on materials provided by Ume universitet. Note: Materials may be edited for content and length.


Cite This Page:

Ume universitet. "Leptin may explain link between abdominal obesity, cardiovascular disease." ScienceDaily. ScienceDaily, 7 October 2013. <www.sciencedaily.com/releases/2013/10/131007094332.htm>.
Ume universitet. (2013, October 7). Leptin may explain link between abdominal obesity, cardiovascular disease. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/10/131007094332.htm
Ume universitet. "Leptin may explain link between abdominal obesity, cardiovascular disease." ScienceDaily. www.sciencedaily.com/releases/2013/10/131007094332.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins