Featured Research

from universities, journals, and other organizations

How JC Polyomavirus invades cells

Date:
October 7, 2013
Source:
Brown University
Summary:
A new study identifies the means by which the JC Polyomavirus enters host cells. It's a particular subset of serotonin receptors.

For more than a decade the research group of Brown University Professor Walter Atwood has doggedly pursued the workings of the JC polyomavirus, which causes a disease called PML that fatally degrades the central nervous system of patients with weakened immune systems. In a study published online Oct. 2 in the Journal of Virology, his team describes how it gains entry into cells: It breaks in via certain receptors of the neurotransmitter serotonin called 5-HT2 receptors.

Atwood, lead author and graduate student Benedetta Assetta and their co-authors showed this by inserting more than a dozen different serotonin receptors into cells that normally can't be infected. Of all 14 receptors, only the three 5HT-2 receptors facilitated infection.

"This paper is significant because it re-defines the role that serotonin receptors play in JC Polyomavirus infection," Atwood said. "Our initial hypothesis was that these receptors played a direct role in virus binding to cells. We now know that this is incorrect. A second carbohydrate molecule, LSTc, is what facilitates binding and we confirm that here."

The research, Atwood said, could lead to improved treatment for PML, for instance by informing how existing drugs work.

"The present study provides new insights on three different serotonin receptors which are potential drug targets," Atwood said. "Several 5-HT2 receptor inhibitors, both selective and non-selective, are FDA-approved and commonly used to treat neurological disorders. One of these drugs, mirtazapine, has been administered in patients with PML and results have been mixed but it does appear that the use of mirtazapine is most successful if administered early at the onset of PML symptoms."

The researchers are now looking at why these three specific serotonin receptors facilitate infection, while the others do not.


Story Source:

The above story is based on materials provided by Brown University. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. Assetta, M. S. Maginnis, I. Gracia Ahufinger, S. A. Haley, G. V. Gee, C. D. S. Nelson, B. A. O'Hara, S.-a. A. Allen Ramdial, W. J. Atwood. 5-HT2 RECEPTORS FACILITATE JC POLYOMAVIRUS ENTRY. Journal of Virology, 2013; DOI: 10.1128/JVI.02252-13

Cite This Page:

Brown University. "How JC Polyomavirus invades cells." ScienceDaily. ScienceDaily, 7 October 2013. <www.sciencedaily.com/releases/2013/10/131007122644.htm>.
Brown University. (2013, October 7). How JC Polyomavirus invades cells. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2013/10/131007122644.htm
Brown University. "How JC Polyomavirus invades cells." ScienceDaily. www.sciencedaily.com/releases/2013/10/131007122644.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins