Featured Research

from universities, journals, and other organizations

Research team designing new drug for common heart condition

Date:
October 7, 2013
Source:
University of Alberta Faculty of Medicine & Dentistry
Summary:
An international research team has shown that new medications based on resveratrol -- a compound found in red wine and nuts -- may be used to treat a common heart-rhythm problem known as atrial fibrillation.

An international research team led by medical scientists at the University of Alberta has shown that new medications based on resveratrol -- a compound found in red wine and nuts -- may be used to treat a common heart-rhythm problem known as atrial fibrillation.

Faculty of Medicine & Dentistry researcher Peter Light and his colleagues recently published their findings in the peer-reviewed journal, British Journal of Pharmacology. They discovered that new resveratrol-based drugs they created that were used in the lab, helped regulate electrical activity in the heart by inhibiting irregular electrical currents, and by reducing the length of abnormal heart-rhythm episodes. These new medications they created targeted multiple activities in the cell, whereas current medications for heart rhythm problems target just one or two specific areas.

The U of A team is now working on advancing their drug design with colleagues at the Centre for Drug Research and Development, and via TEC Edmonton. Light expects that clinical trials with the advanced drug design will start within the next three to five years.

"We are at the next stage of developing a new oral medication for atrial fibrillation that patients could take on a daily basis to prevent this condition from occurring," says Light. "We are improving the medication's solubility, absorption, how it is metabolized and how long it stays in the blood stream."

Few medications are currently on the market to help treat atrial fibrillation effectively and those medications may have many serious side effects. Because resveratrol is a natural product, Light and his colleagues hope the new drug would be better tolerated by the body.

It has long been known that resveratrol has cardio-protective effects and seems to prevent some rhythm disorders of the heart, lowers blood pressure and reduces enlargement of the heart.

"We have had a tremendous amount of success with resveratrol and have been at the leading edge of resveratrol research as it relates to cardiovascular disease so the transition to making new and improved medications based on resveratrol derivatives is a logical next step," says Jason Dyck, one of the researchers on the team.

Atrial fibrillation is the most common abnormal heart rhythm problem affecting 1 in 200 people. It carries a five-fold increased risk of stroke, as well as an increased risk of heart failure and death.


Story Source:

The above story is based on materials provided by University of Alberta Faculty of Medicine & Dentistry. Note: Materials may be edited for content and length.


Journal Reference:

  1. Istvan Baczko, David Liknes, Wei Yang, Kevin C Hamming, Gavin Searle, Kristian Jaeger, Zoltan Husti, Viktor Juhasz, Gergely Klausz, Robert Pap, Laszlo Saghy, Andras Varro, Vernon Dolinsky, Shaohua Wang, Vivek Rauniyar, Dennis Hall, Jason R. Dyck, Peter E. Light. Characterization of a novel multi-functional resveratrol derivative for the treatment of atrial fibrillation.. British Journal of Pharmacology, 2013; DOI: 10.1111/bph.12409

Cite This Page:

University of Alberta Faculty of Medicine & Dentistry. "Research team designing new drug for common heart condition." ScienceDaily. ScienceDaily, 7 October 2013. <www.sciencedaily.com/releases/2013/10/131007132248.htm>.
University of Alberta Faculty of Medicine & Dentistry. (2013, October 7). Research team designing new drug for common heart condition. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2013/10/131007132248.htm
University of Alberta Faculty of Medicine & Dentistry. "Research team designing new drug for common heart condition." ScienceDaily. www.sciencedaily.com/releases/2013/10/131007132248.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins