Featured Research

from universities, journals, and other organizations

People born with certain gene more likely to suffer cognitive decline after heart surgery

Date:
October 13, 2013
Source:
American Society of Anesthesiologists (ASA)
Summary:
Long-term memory loss, difficulty understanding verbal or written communication or impaired ability to pay attention may still occur five years after heart surgery if a patient has a certain gene variation, according to a study. This gene was found to be related to a decline in cognitive capabilities compared to those who do not have the variation.

Long-term memory loss, difficulty understanding verbal or written communication or impaired ability to pay attention may still occur five years after heart surgery if a patient has a certain gene variation, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting. This gene was found to be related to a decline in cognitive capabilities compared to those who do not have the variation.

Thirty to 50 percent of patients experience a decrease in cognitive function after heart surgery and neurologic injury is one of the most common adverse side effects. Examples of neurologic injuries include stroke, memory loss, difficulties with problem-solving and impaired attention.

"Whether cognitive decline seen after surgery is a side effect of the surgery and anesthesia or a progression of other neurologic disease remains a matter of debate," said Karsten Bartels, M.D., who helped conduct this study while a fellow in cardiothoracic anesthesiology and critical care medicine under the direction of Joseph Mathew, M.D., professor of anesthesiology at Duke University Medical Center, Durham, N.C. "Our study found that if a patient has this gene variation (APOE4), that person is more likely to have cognitive decline five years after surgery."

People are born with the gene variation Apolipoprotein E4 (APOE4), which can be identified through a genetic blood test. Apolipoproteins are important gatekeepers of cholesterol metabolism and inflammation, according to Dr. Bartels. The protein structure of these apolipoproteins is determined by a person's DNA; however, minor variations are not uncommon. Such minor variations in the genetic code can have serious consequences. APOE4 has been identified as both a driver and marker of accelerated neurologic dysfunction, including in Alzheimer's disease.

In the study, the authors reviewed data from 233 elderly, Caucasian cardiac patients who had heart surgery. The patients were administered a battery of neuropsychological assessments just before surgery and five years after. Cognitive function was assessed with a composite cognitive index score. The change in cognitive function five years after surgery was adjusted for age, years of education and cognitive score prior to surgery.

The study found that the mean change in cognitive index score over five years for patients without the gene variation was 0.16, while the score for patients who have the APOE4 gene variation was .08. These results indicate a less favorable outcome for carriers of the APOE4 gene.

"Our findings suggest that the long-term cognitive decline previously seen after surgery is related more to the patient's genetic makeup than to the surgery itself," continued Dr. Bartels. "Knowing which patients have the APOE4 genotype can help doctors assess the risk for cognitive problems following surgery, ultimately allowing patients to make better-informed decisions and permitting doctors to direct strategies to protect the brain after surgery."


Story Source:

The above story is based on materials provided by American Society of Anesthesiologists (ASA). Note: Materials may be edited for content and length.


Cite This Page:

American Society of Anesthesiologists (ASA). "People born with certain gene more likely to suffer cognitive decline after heart surgery." ScienceDaily. ScienceDaily, 13 October 2013. <www.sciencedaily.com/releases/2013/10/131013121725.htm>.
American Society of Anesthesiologists (ASA). (2013, October 13). People born with certain gene more likely to suffer cognitive decline after heart surgery. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2013/10/131013121725.htm
American Society of Anesthesiologists (ASA). "People born with certain gene more likely to suffer cognitive decline after heart surgery." ScienceDaily. www.sciencedaily.com/releases/2013/10/131013121725.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins