Featured Research

from universities, journals, and other organizations

New drug regimen reduces post-op nausea, vomiting in bariatric surgery patients

Date:
October 13, 2013
Source:
American Society of Anesthesiologists (ASA)
Summary:
Ninety-seven percent of bariatric surgery patients avoided post-operative nausea and vomiting (PONV) with the addition of a second drug to the standard treatment given during surgery.

Ninety-seven percent of bariatric surgery patients avoided post-operative nausea and vomiting (PONV) with the addition of a second drug to the standard treatment given during surgery, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting.

"Nausea and vomiting are some of the most common post-op complications for all patients who have general anesthesia," said Ashish C. Sinha, M.D., Ph.D., vice chair of anesthesiology and perioperative medicine at Drexel University College of Medicine, Philadelphia. "However after weight-loss surgery, the consequences of vomiting can be very serious. During this kind of surgery, the stomach is transformed to a small, one-ounce sac. Vomiting risks rupturing the fresh incision as the contents of the stomach try to violently exit the narrow, freshly created stomach pouch. Reducing this risk would mean more comfortable patients as well as safer surgery and anesthesia."

An estimated 113,000 people in the United States have bariatric weight-loss surgery annually, according to the American Journal of Surgery. Approximately 15 million, or one in 50 American adults, are morbidly obese, which is associated with more than 30 diseases and conditions, including type 2 diabetes, heart disease, obstructive sleep apnea, hypertension, asthma, cancer, osteoarthritis and infertility. The direct and indirect costs to the health care system associated with obesity are about $147 billion annually, according to the American Society for Metabolic and Bariatric Surgery. These costs are expected to increase to $344 billion in five years, if obesity rates continue to increase at the current pace.

The study included 124 patients. Within one hour of the anticipated start of anesthesia, 64 people received the combination treatment of Zofran (the standard therapy) plus aprepitant; the remaining 60 patients got the Zofran and a placebo. Nausea was assessed with a 10-point scale after surgery at intervals of 30 minutes, one, two, six, 24 , 48 and 72 hours.

The study found that only three percent of patients who received the combination treatment experienced PONV. The incidence of vomiting was 15 percent in the placebo group who received Zofran alone.

"This multi-drug therapy can benefit patients at higher risk for PONV," continued Dr. Sinha. "There are multiple receptors in the brain stem that trigger vomiting; if we use the combination therapy, we can increase the number of receptors blocked and lower the incidence of vomiting.


Story Source:

The above story is based on materials provided by American Society of Anesthesiologists (ASA). Note: Materials may be edited for content and length.


Cite This Page:

American Society of Anesthesiologists (ASA). "New drug regimen reduces post-op nausea, vomiting in bariatric surgery patients." ScienceDaily. ScienceDaily, 13 October 2013. <www.sciencedaily.com/releases/2013/10/131013202927.htm>.
American Society of Anesthesiologists (ASA). (2013, October 13). New drug regimen reduces post-op nausea, vomiting in bariatric surgery patients. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/10/131013202927.htm
American Society of Anesthesiologists (ASA). "New drug regimen reduces post-op nausea, vomiting in bariatric surgery patients." ScienceDaily. www.sciencedaily.com/releases/2013/10/131013202927.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins