Featured Research

from universities, journals, and other organizations

New therapeutic target identified for deadly thyroid carcinomas

Date:
October 16, 2013
Source:
American Thyroid Association
Summary:
A novel drug target, and evidence of the strong anti-tumor effects of an inhibitor capable of blocking expression of the target are described in new research.

Anaplastic thyroid carcinomas (ATC) are aggressive tumors that do not respond to traditional radio- or chemotherapeutic agents, and there currently is no cure or effective treatment available. Median survival from diagnosis is 5 months, and although ATC accounts for only 1.7% of all thyroid cancers in the U.S., it is responsible for a large proportion of thyroid cancer-related deaths. A novel drug target, and evidence of the strong anti-tumor effects of an inhibitor capable of blocking expression of the target are described in a poster to be presented at the 83rd Annual Meeting of the American Thyroid Association, October 16-20, 2013, in San Juan, Puerto Rico.

Christina von Roemeling and colleagues from The Mayo Clinic, Jacksonville, FL, found that the enzyme stearoyl-CoA desaturase 1 (SCD1), which has a role in fatty acid metabolism, is expressed at high levels in tissue samples from patients with papillary thyroid carcinoma (PTC), high grade follicular thyroid carcinoma (FTC), and ATC. An inhibitor of SCD1 expression demonstrated strong anti-tumor activity--reduced tumor cell proliferation and increased cell death--specifically in ATC cells and showed little to no activity in PTC or FTC cells. The sequential addition of a proteasome inhibitor led to a synergistic effect and enhanced anti-tumor activity in ATC cells. The researchers propose the combined use of an SCD1 inhibitor and a proteasome inhibitor as a new treatment regimen that might benefit patients with ATC.

"Since anaplastic thyroid cancer is one of the most aggressive and least treatable of all cancers, new therapies are desperately needed," says Ronald J. Koenig, M.D., Ph.D, Program Committee Co-Chair, and Professor, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor. "The study by von Roemeling and colleagues is important because they show that drugs that inhibit the enzyme SCD1 can kill anaplastic thyroid cancer cells in a culture dish. This exciting finding will need to be tested in animal models of anaplastic thyroid cancer before consideration of clinical trials, but it offers hope for a disease very much in need of new therapies."


Story Source:

The above story is based on materials provided by American Thyroid Association. Note: Materials may be edited for content and length.


Cite This Page:

American Thyroid Association. "New therapeutic target identified for deadly thyroid carcinomas." ScienceDaily. ScienceDaily, 16 October 2013. <www.sciencedaily.com/releases/2013/10/131016095845.htm>.
American Thyroid Association. (2013, October 16). New therapeutic target identified for deadly thyroid carcinomas. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2013/10/131016095845.htm
American Thyroid Association. "New therapeutic target identified for deadly thyroid carcinomas." ScienceDaily. www.sciencedaily.com/releases/2013/10/131016095845.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins