Featured Research

from universities, journals, and other organizations

Researcher learns how to break a sweat

Date:
October 23, 2013
Source:
University of Southern California - Health Sciences
Summary:
Without sweat, we would overheat and die. In a recent paper, a team of researchers explored the ultimate origin of this sticky, stinky but vital substance -- sweat gland stem cells.

Staining of slow-cycling sweat gland cells (green) with the protein laminin (red) and the fluorescent stain DAPI (blue).
Credit: Yvonne Leung

Without sweat, we would overheat and die. In a recent paper in the journal Public Library of Science One (PLOS ONE), USC faculty member Krzysztof Kobielak and a team of researchers explored the ultimate origin of this sticky, stinky but vital substance -- sweat gland stem cells.

Related Articles


Kobielak and his team used a system to make all of the sweat gland cells in a mouse easy to spot: labeling them with green fluorescent protein (GFP), which is visible under ultraviolet light.

Over time, the GFP became dimmer as it was diluted among dividing sweat gland cells. After four weeks, the only cells that remained fluorescent were the ones that did not divide or divided very slowly -- a known property among stem cells of certain tissues, including the hair follicle and cornea. Therefore, these slow-dividing, fluorescent cells in the sweat gland's coiled lower region were likely also stem cells.

Then, the first author of this paper, graduate student Yvonne Leung, tested whether these fluorescent cells could do what stem cells do best -- differentiate into multiple cell types. To the researchers' surprise, these glowing cells generated not only sweat glands, but also hair follicles when placed in the skin of a mouse without GFP.

The researchers also determined that under certain conditions, the sweat gland stem cells could heal skin wounds and regenerate all layers of the epidermis.

"That was a big surprise for us that those very quiescent sweat gland stem cells maintain multilineage plasticity -- participating not only in their own regeneration, but also in the regeneration of hair follicles and skin after injury," said Kobielak, assistant professor of pathology at the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.

This offers exciting possibilities for developing future stem cell-based treatments for skin and sweat gland-related conditions, such as hyperhidrosis or hypohidrosis (excessive or insufficient sweating). It could also lay the foundation for creating fully functional skin -- containing both sweat glands and hair follicles -- for burn victims.


Story Source:

The above story is based on materials provided by University of Southern California - Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yvonne Leung, Eve Kandyba, Yi-Bu Chen, Seth Ruffins, Krzysztof Kobielak. Label Retaining Cells (LRCs) with Myoepithelial Characteristic from the Proximal Acinar Region Define Stem Cells in the Sweat Gland. PLoS ONE, 2013; 8 (9): e74174 DOI: 10.1371/journal.pone.0074174

Cite This Page:

University of Southern California - Health Sciences. "Researcher learns how to break a sweat." ScienceDaily. ScienceDaily, 23 October 2013. <www.sciencedaily.com/releases/2013/10/131023183911.htm>.
University of Southern California - Health Sciences. (2013, October 23). Researcher learns how to break a sweat. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/10/131023183911.htm
University of Southern California - Health Sciences. "Researcher learns how to break a sweat." ScienceDaily. www.sciencedaily.com/releases/2013/10/131023183911.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins