Featured Research

from universities, journals, and other organizations

Genetic factors predispose metabolic syndrome in mixed races

Date:
October 24, 2013
Source:
Investigación y Desarrollo
Summary:
Researchers have carried out a study on genetic factors that can be associated to metabolic syndrome, main trigger of cardiovascular diseases, type II diabetes and obesity, with the goal of identifying high risk populations and influence its treatment in the most effective way. The objective was to review the genetic susceptibility of the mixed and indigenous Mexican populations to developing metabolic syndrome or one of its components, and the relationship of this risk with its indigenous, Caucasian or African origins.

Researchers from the Institute of Genomic Medicine (Inmegen) carried out a study on genetic factors that can be associated to metabolic syndrome, main trigger of cardiovascular diseases, type II diabetes and obesity, with the goal of identifying high risk populations and influence its treatment in the most effective way.

Under the lead of Lorena Orozco, the objective of the research is to know the genetic susceptibility of the mixed and indigenous Mexican populations to developing metabolic syndrome or one of its components and the relationship of this risk with its indigenous, Caucasian or African origins.

The researcher explained that the metabolic syndrome is characterized by the simultaneous presence or sequence of at least three of the next components: increment in glucose levels, triglycerides, arterial hypertension, low levels of benefic cholesterol (HDL) and rise of the waist circumference.

She also said that the study includes individuals from different Mexican states throughout the country, like Chiapas, San Luis Potosí, Mexico State, Yucatán, Chihuahua, Oaxaca, Puebla and Mexico City.

The project's study group was integrated by 800 mixed race individuals and 400 natives more than 30 years old, from both sexes. Blood samples were taken from this groups in order to know their cholesterol, triglycerides, glucose and blood pressure levels, as well as their body mass, size, weight and height.

In this stage of the study, it was founded that 42 per cent of the mixed population suffered from metabolic syndrome and 10 per cent had type II diabetes.

Regarding the indigenous group, the results showed that there were communities like the Tojolabales form Chiapas, where type II diabetes was barely present, contrasting with other groups like the Totonacas from Veracruz, were the prevalence of this disease was near a 25 per cent. It was also found that 45 per cent of the Tarahumaras from Chihuahua that were tested had high blood pressure.

In another phase of the project, DNA from each individual was analyzed to evaluate the intervention of three genes (AKT1, GCKR and ADIPOQ) that participate in the metabolism of glucose or fatty acids.

"We are heirs of a genetics that in a hostile environment, thousands of years ago, helped us survive long periods of famine and other hardships. However, in the present, this genetics is the detonator of diseases such as diabetes, obesity and metabolic syndrome," emphasized the researcher.

Regarding the main discoveries, the researchers observed that in the mixed population there are variations in the sequence of ADIPOQ and GCKR genes that are associated to the rise of triglycerides in the blood stream. Meanwhile, the variations of the gene AKT1 are related with low levels of benefic cholesterol.

Another important discovery was that the genetic variations in the AKT1 gene come mainly from the Caucasian component of the mixed-Mexican population, whereas in the case of ADIPOQ and GCKR genes the mutations are integrated by indigenous and Caucasian origins.

According to the researcher, the next stage of the project is to expand to 400 more individuals in both groups. By detecting genetic variations in mixed and indigenous populations that are in risk of developing metabolic syndrome, future models of treatment can be made more efficient and even a predictive diagnosis of the disease could be implemented.

Globally, the prevalence of the metabolic syndrome is between 30 and 50 per cent of the population and in Mexico it reaches a 42 per cent, the women having a greater probability of manifesting it.


Story Source:

The above story is based on materials provided by Investigación y Desarrollo. Note: Materials may be edited for content and length.


Cite This Page:

Investigación y Desarrollo. "Genetic factors predispose metabolic syndrome in mixed races." ScienceDaily. ScienceDaily, 24 October 2013. <www.sciencedaily.com/releases/2013/10/131024090041.htm>.
Investigación y Desarrollo. (2013, October 24). Genetic factors predispose metabolic syndrome in mixed races. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/10/131024090041.htm
Investigación y Desarrollo. "Genetic factors predispose metabolic syndrome in mixed races." ScienceDaily. www.sciencedaily.com/releases/2013/10/131024090041.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins