Featured Research

from universities, journals, and other organizations

Understanding DNA damage from common radiation threat, low-energy electrons

Date:
October 25, 2013
Source:
American Institute of Physics (AIP)
Summary:
Every day, all day, our DNA gets beaten up by chemicals and radiation -- but remarkably, most of us stay healthy. Now, an investigation has produced insights into a little-studied but common radiation threat to DNA: low-energy electrons (LEEs), with energies of 0-15 electron volts.

Every day, all day, our DNA gets beaten up by chemicals and radiation -- but remarkably, most of us stay healthy. Now, an investigation by a team of French and Canadian researchers has produced insights into a little-studied but common radiation threat to DNA: low-energy electrons (LEEs), with energies of 0-15 electron volts.

The team has devised the first rough model of a close DNA cellular environment under threat from LEEs, revealing for the first time their effects on DNA in natural, biological conditions. Their work appears in The Journal of Chemical Physics, which is produced by AIP Publishing

The team's work is an important step forward in understanding how LEEs injure DNA because it provides a realistic experimental platform for analysis of results. The goal is to use this knowledge to improve current uses of radiation, such as in cancer treatments.

"The way by which these electrons can damage DNA, and how much damage they inflict, quantitatively, is of major importance not only for general radiation protection purposes, but also for improving the efficiency and safety of therapeutic and diagnostic radiation therapy," said Michel Fromm, the lead researcher from Université de Franche-Comté in Besançon, France, whose expertise is in creating nanometer-scaled DNA layers. His co-author on the paper is Leon Sanche, of Sherbrooke University Québec, Canada, who is one of the world's leading authorities on LEE research.

The team explored specific features of a small DNA molecule called a plasmid on a specialized thin film they created, which was irradiated by an electron gun. The impact produced transient particles called anions, which dissociate into "pieces" of DNA. When analyzed, these molecular fragments provide insight into the mechanisms of DNA strand breaks and other DNA injuries that health researchers seek to understand, repair and prevent.

"The fascinating point is that each time the close environment of DNA changes, new mechanisms of interaction of LEEs appear," Fromm said.


Story Source:

The above story is based on materials provided by American Institute of Physics (AIP). Note: Materials may be edited for content and length.


Journal Reference:

  1. Omar Boulanouar, Michel Fromm, Christophe Mavon, Pierre Cloutier, Léon Sanche. Dissociative electron attachment to DNA-diamine thin films: Impact of the DNA close environment on the OH− and O− decay channels. The Journal of Chemical Physics, 2013; 139 (5): 055101 DOI: 10.1063/1.4815967

Cite This Page:

American Institute of Physics (AIP). "Understanding DNA damage from common radiation threat, low-energy electrons." ScienceDaily. ScienceDaily, 25 October 2013. <www.sciencedaily.com/releases/2013/10/131025123054.htm>.
American Institute of Physics (AIP). (2013, October 25). Understanding DNA damage from common radiation threat, low-energy electrons. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/10/131025123054.htm
American Institute of Physics (AIP). "Understanding DNA damage from common radiation threat, low-energy electrons." ScienceDaily. www.sciencedaily.com/releases/2013/10/131025123054.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) — In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) — The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins