Featured Research

from universities, journals, and other organizations

'Good' cholesterol controls blood glucose

Date:
October 30, 2013
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
High density lipoprotein cholesterol (HDL), the so-called “good“ cholesterol, improves blood glucose levels by enhancing skeletal muscle function and reducing adiposity, scientists report.

High density lipoprotein cholesterol (HDL), the so-called "good" cholesterol improves blood glucose levels by enhancing skeletal muscle function and reducing adiposity, scientists of the Helmholtz Zentrum München report in the current issue of the renown American Heart Association Journal ‚Circulation'.

Related Articles


Atherosclerotic cardiovascular disease rates are markedly increased in individuals with type 2 diabetes. One of the strongest independent predictors of cardiovascular disease in these patients is a low circulating level of high density lipoprotein (HDL) cholesterol and its major protein constituent apolipoprotein A-I (ApoA-I). An international team of scientists led by Dr. Susanna Hofmann from the Institute of Diabetes and Regeneration Research at the Helmholtz Zentrum München (HMGU), Partner of the German Center for Diabetes Research (DZD), and Dr. Maarit Lehti from the LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland, have now determined that normal circulating HDL levels are required for proper skeletal muscle metabolism and function.

In their study, Hofmann and her team observed that without ApoA-I, burning of calories is reduced in skeletal muscle resulting in increased blood glucose and weaker muscle function. The scientists then determined that HDL cholesterol and its protein ApoA-I both enhance usage of glucose and calories inside muscle cells. Raising HDL and ApoA-I levels in animal models resulted in protection against hyperglycemia and age-related symptoms such as decline of muscle performance or fat mass gain. Improved calorie burning in mitochondria (the "power plants" in each cell) was further indicated by a marked reduction of circulating Fibroblast Growth Factor 21, a novel biomarker for mitochondrial dysfunction.

"Our results link for the first time low HDL-cholesterol with impaired use of glucose and burning of calories in type 2 diabetes. ApoA-I analogues are now clinically tested for the prevention and regression of atherosclerosis. Based on our findings described herein, these analogs may offer underappreciated potential for therapeutic opportunities in diabetes," explains Hofmann, who investigates interactions of fat and glucose metabolism with her international team. She adds: "Most importantly, our results are highly relevant for women with type 2 diabetes. Their risk for cardiovascular diseases compared to men with type 2 diabetes is significantly increased, because these women have low concentrations of HDL-cholesterol and ApoA-I."


Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lehti, M. et al. High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. Circulation, October 2013

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "'Good' cholesterol controls blood glucose." ScienceDaily. ScienceDaily, 30 October 2013. <www.sciencedaily.com/releases/2013/10/131030103601.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2013, October 30). 'Good' cholesterol controls blood glucose. ScienceDaily. Retrieved March 3, 2015 from www.sciencedaily.com/releases/2013/10/131030103601.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "'Good' cholesterol controls blood glucose." ScienceDaily. www.sciencedaily.com/releases/2013/10/131030103601.htm (accessed March 3, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 3, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins