Featured Research

from universities, journals, and other organizations

Study shows bariatric surgery may turn back the effects of aging

Date:
November 15, 2013
Source:
American Society for Metabolic & Bariatric Surgery (ASMBS)
Summary:
Researchers say surgical weight loss may turn back the effects of aging at a genetic level, in the first study of its kind.

Stanford University researchers say surgical weight loss may turn back the effects of aging at a genetic level, in the first study* of its kind presented here during ObesityWeek 2013, the largest international event focused on the basic science, clinical application and prevention and treatment of obesity. The event is hosted by the American Society for Metabolic and Bariatric Surgery (ASMBS) and The Obesity Society (TOS).

Researchers reviewed genetic data of 51 patients before and after gastric bypass surgery. Most study subjects were women (76.5%), about 49 years old, with an average body mass index (BMI) of 44.3. On average, patients lost 71 percent of their excess weight and saw their C-reactive protein (CRP) level, a measure of inflammation, drop by more than 60 percent (8.3 to 3.6) and experienced a four-fold decline in their fasting insulin (24 to 6), within 12 months of surgery.

These findings are consistent with previous studies on bariatric surgery, but researchers went further. For the first time, they measured the length of each patient's telomeres before and after surgical weight loss. Telomeres are genetic biomarkers that play an important role in cellular aging and in the development of disease. As people age or have chronic disease, their telomeres become shorter.

Researchers discovered after gastric bypass, certain patients' telomeres actually became longer. Preoperative patients with high levels of LDL cholesterol, the so called "bad cholesterol," and high levels of inflammation (CRP), not only saw these levels drop within a year of surgery, they also experienced significant lengthening of their telomeres, when compared to patients with initial low LDL and CRP levels.

"Obesity has an adverse effect on health, causes pre-mature aging and reduces life expectancy. This is the first study to show that surgical weight loss may be able to reverse the effects," said study co-author John M. Morton, MD, Chief of Bariatric Surgery at Stanford University Medical Center and President-Elect of the ASMBS. "If your telomeres get longer, you're likely to reverse the effects of aging and have a lower risk of developing a wide range of age-related diseases such as type 2 diabetes, heart and respiratory diseases, and certain types of cancer."

In the high preoperative CRP group, there was a significant positive correlation between weight loss and telomere length and in the high preoperative LDL group, increases in HDL, the so called "good cholesterol," were associated with increases in telomere length. Researchers measured telomere length using laboratory blood testing that targets and measures specific DNA sequences.

Researchers say further studies are needed to confirm the direct effects of telomere length on health outcomes.


Story Source:

The above story is based on materials provided by American Society for Metabolic & Bariatric Surgery (ASMBS). Note: Materials may be edited for content and length.


Cite This Page:

American Society for Metabolic & Bariatric Surgery (ASMBS). "Study shows bariatric surgery may turn back the effects of aging." ScienceDaily. ScienceDaily, 15 November 2013. <www.sciencedaily.com/releases/2013/11/131115093715.htm>.
American Society for Metabolic & Bariatric Surgery (ASMBS). (2013, November 15). Study shows bariatric surgery may turn back the effects of aging. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2013/11/131115093715.htm
American Society for Metabolic & Bariatric Surgery (ASMBS). "Study shows bariatric surgery may turn back the effects of aging." ScienceDaily. www.sciencedaily.com/releases/2013/11/131115093715.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins