Featured Research

from universities, journals, and other organizations

Blood growth factor boosts effect of exercise in peripheral artery disease

Date:
November 18, 2013
Source:
Emory Health Sciences
Summary:
A blood cell growth factor can boost the effects of exercise in improving mobility for patients with peripheral artery disease, according to research.

A blood cell growth factor can boost the effects of exercise in improving mobility for patients with peripheral artery disease, a clinical study has shown.

The results were presented Nov. 18, 2013 at the American Heart Association Scientific Sessions meeting in Dallas.

Researchers at Emory University School of Medicine were testing whether GM-CSF (granulocyte-macrophage colony stimulating factor), already used to restore white blood cell numbers during cancer treatment, could help heal blood vessels damaged by atherosclerosis.

In peripheral artery disease, patients' legs have trouble getting enough blood during exercise, leading to impaired mobility and pain after exertion. The primary outcome measured in the study was how long participants could walk on a treadmill two months after a four-week course of either GM-CSF injections or placebo.

"We saw a modest increase in treadmill walking time for patients treated with GM-CSF, compared to placebo," says study leader Arshed Quyyumi, MD, professor of medicine at Emory University School of Medicine and co-director of the Emory Clinical Cardiovascular Research Institute. "However, we also saw something encouraging. The patients who strongly responded to GM-CSF, measured by the levels of progenitor cells in their blood, also saw more benefit in terms of maximum walking time. Changes in the dose and duration of GM-CSF treatment could possibly enhance therapeutic benefit, and this needs more investigation."

At the start of the study, both groups could walk on a treadmill for a maximum of about five minutes. On average, study participants who received GM-CSF had their maximum walking time increase almost a minute (53 seconds) more than the placebo group, although the difference was not statistically significant.

Both groups of patients were encouraged to walk several times per day, and both GM-CSF and placebo groups saw increases in their ability to walk (30 percent increase for GM-CSF compared to 21 percent increase for placebo). A total of 159 patients participated in the phase II study, all at Emory-affiliated medical centers from 2010 to 2012.

GM-CSF is thought to act by moving progenitor cells out of the bone marrow so that they can replenish the linings of blood vessels. In the Emory study, there was some variability in how much individual patients responded to GM-CSF.

Some patients who received GM-CSF experienced above-average increases in the levels of progenitor cells, defined as carrying the marker CD34. They also experienced greater increases in their ability to walk, with treadmill times in this group increasing more than two minutes on average.

Overall, the PAD patients' responses to GM-CSF were less than what has been observed in healthy individuals. This may be because of poor health and especially atherosclerosis have affected the health of the bone marrow, although people with recent heart attacks or other severe disease were excluded from the study, Quyyumi says. Participants had an average age of 64 and 37 percent of them were diabetic. However, age and diabetes did not predict patients' ability to respond to GM-CSF.


Story Source:

The above story is based on materials provided by Emory Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

Emory Health Sciences. "Blood growth factor boosts effect of exercise in peripheral artery disease." ScienceDaily. ScienceDaily, 18 November 2013. <www.sciencedaily.com/releases/2013/11/131118102620.htm>.
Emory Health Sciences. (2013, November 18). Blood growth factor boosts effect of exercise in peripheral artery disease. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2013/11/131118102620.htm
Emory Health Sciences. "Blood growth factor boosts effect of exercise in peripheral artery disease." ScienceDaily. www.sciencedaily.com/releases/2013/11/131118102620.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins