Featured Research

from universities, journals, and other organizations

Decreased diversity of bacteria microbiome in gut associated colorectal cancer

Date:
December 6, 2013
Source:
Journal of the National Cancer Institute
Summary:
Decreased diversity in the microbial community found in the human gut is associated with colorectal cancer, according to a new study published.

Decreased diversity in the microbial community found in the human gut is associated with colorectal cancer, according to a new study published December 6 in the Journal of the National Cancer Institute.

Previous studies suggest a role for the gut microbiota in colorectal cancer (CRC), but comprehensive epidemiological studies comparing samples from case and control subjects that also consider potential confounders and adjust for multiple comparisons inherently involved in microbiome analysis have not been reported.

Jiyoung Ahn, Ph.D., from Department of Population Health at New York University School of Medicine in New York, NY, and colleagues compared samples and data from participants enrolled in a case-control study. DNA was extracted from fecal samples from 47 case subjects and 94 sex- and body mass index-matched control subjects and was sequenced to determine the gut microbial community structure of case vs control subjects. Odds ratios to determine the relationship between gut microbiota of case subjects vs control subjects were calculated using logistic regression analysis after adjusting for age, sex, BMI, race, smoking, and sequencing batch. They found decreased bacterial diversity in the gut was associated with CRC risk.

The authors highlight several trends in abundance of some key bacteria in the fecal samples they analyzed from case and control subjects that contribute to the decreased diversity associated with CRC risk which they report. Case subjects showed decreased levels of Clostridia, which include some bacterial family members that ferment dietary fiber, to butyrate, which is a major colonic metabolite that may inhibit inflammation and carcinogenesis in the colon. Also of note, increased levels of Fusobacterium and Porphyromonas, bacteria related to inflammation in in the mouth and gastrointestinal track was observed for case vs control subjects.

The authors write, "Because of the potentially modifiable nature of the gut bacteria, our findings may have implications for CRC prevention."

In an accompanying editorial, Volker Mai, Ph.D., M.P.H., and J. Glenn Morris, Jr., M.D., M.P.H., T.M. from the University of Florida at Gainesville FL, say the findings by Ahn et al. are exciting. However, they also write, "CRC occurrence is known to be influenced by host genetics, as well as factors such as obesity, nutrition and exercise; given that these factors also influence microbiota, separation of cause and effect among all of these factors may become quite difficult." Mai and Morris conclude that prospective cohort studies are therefore warranted.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Ahn, R. Sinha, Z. Pei, C. Dominianni, J. Wu, J. Shi, J. J. Goedert, R. B. Hayes, L. Yang. Human Gut Microbiome and Risk of Colorectal Cancer. JNCI Journal of the National Cancer Institute, 2013; DOI: 10.1093/jnci/djt300

Cite This Page:

Journal of the National Cancer Institute. "Decreased diversity of bacteria microbiome in gut associated colorectal cancer." ScienceDaily. ScienceDaily, 6 December 2013. <www.sciencedaily.com/releases/2013/12/131206163051.htm>.
Journal of the National Cancer Institute. (2013, December 6). Decreased diversity of bacteria microbiome in gut associated colorectal cancer. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/12/131206163051.htm
Journal of the National Cancer Institute. "Decreased diversity of bacteria microbiome in gut associated colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2013/12/131206163051.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins