Featured Research

from universities, journals, and other organizations

Open Access Article on Biological Effects of the Popular Artificial Sweetener Sucralose

Date:
December 12, 2013
Source:
Taylor & Francis
Summary:
The artificial sweetener sucralose is a biologically active compound according to an extensive review.

The artificial sweetener sucralose is a biologically active compound according to an extensive review published by Taylor & Francis in the recent issue of Journal of Toxicology and Environmental Health, Part B: Critical Reviews. "Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues" authored by Susan S. Schiffman, PhD, an internationally known sweetener researcher and Kristina I. Rother, MD, MHSc, of the National Institutes of Health (NIH), summarizes the biological properties of sucralose based on hundreds of archival, peer-reviewed scientific journal publications.

Some of the biological effects of sucralose described by Schiffman and Rother include:

  • alterations in insulin, blood glucose, and glucagon-like peptide 1 (GLP-1) levels,
  • metabolism of sucralose in the gastrointestinal tract to metabolites whose identity and safety profile are unknown,
  • induction of cyctochrome P450 and P-glycoprotein in the gastrointestinal tract to levels that may limit the bioavailability of therapeutic drugs,
  • reduction in the number and balance of beneficial bacteria in the gastrointestinal tract,
  • histopathological findings in gastrointestinal tract including lymphocytic infiltrates into epithelium, epithelial scarring, mild depletion of goblet cells and glandular disorganization in the colon,
  • decomposition and generation of chloropropanols (a potentially toxic class of compounds) during baking, and
  • mutagenic alterations using several types of biological assays

Schiffman and Rother present scientific evidence from numerous laboratories that most of these biological effects occur at sucralose dosages approved for use in the food supply by global health authorities. Overall, the scientific data presented in the review indicate that sucralose possesses many characteristics in common with other organochlorine compounds such as organochlorine drugs, pesticides, and industrial chemicals. The authors conclude that a careful reassessment of safety is needed regarding the use of sucralose by the general population, particularly special populations such as children, elderly, nursing mothers, persons with diabetes, cancer patients, and persons taking multiple medications.


Story Source:

The above story is based on materials provided by Taylor & Francis. Note: Materials may be edited for content and length.


Journal Reference:

  1. Susan S. Schiffman, Kristina I. Rother. Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues. Journal of Toxicology and Environmental Health, Part B, 2013; 16 (7): 399 DOI: 10.1080/10937404.2013.842523

Cite This Page:

Taylor & Francis. "Open Access Article on Biological Effects of the Popular Artificial Sweetener Sucralose." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212095900.htm>.
Taylor & Francis. (2013, December 12). Open Access Article on Biological Effects of the Popular Artificial Sweetener Sucralose. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2013/12/131212095900.htm
Taylor & Francis. "Open Access Article on Biological Effects of the Popular Artificial Sweetener Sucralose." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212095900.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins