Featured Research

from universities, journals, and other organizations

New guidelines for severe asthma provide updated treatment, definition of disease

Date:
December 12, 2013
Source:
European Lung Foundation
Summary:
A new guideline has provided an updated definition of severe asthma along with new recommendations for treating the condition.

A new guideline has provided an updated definition of severe asthma along with new recommendations for treating the condition.

Produced by a joint task force of the European Respiratory Society and the American Thoracic Society, the guideline is published online today (12 December 2013) in the European Respiratory Journal.

Although severe asthma is estimated to account for less than 10% of all asthmatics, these patients have the greatest burden and require a disproportionate amount of healthcare costs to be spent on treating their condition, which is harder to control.

The guideline defines severe asthma as "asthma which requires treatment with high dose inhaled corticosteroids (ICS) plus a second controller (long acting β2 agonist (LABA), leukotriene modifier, theophylline or systemic corticosteroids) to prevent it from becoming uncontrolled or which remains uncontrolled despite this therapy."

The definition is intended to help doctors to confirm a diagnosis of severe asthma and address associated factors that could be making asthma difficult to treat.

The guideline provides a detailed discussion of the classification (phenotyping) of patients with severe asthma as evidence suggests that severe asthma affects people in different ways.

Recent research has started to group severe asthma into different types (or phenotypes) based on clinical and certain biological features of the condition. These findings can help researchers develop targeted treatments for this group of people whose asthma remains difficult to treat despite taking the recommended therapies. The guideline encourages continuing research into phenotyping severe asthma and finding more effective treatments aimed particularly at specific phenotypes of severe asthma.

The document has produced recommendations using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) method on the evaluation and treatment of severe asthma. Recommendations were made on five treatments that have been used or proposed for use in severe asthma namely anti-IgE treatment, methotrexate, anti-fungal treatment, macrolide antibiotics and bronchial thermoplasty.

Co-lead author, Professor Fan Chung, from Imperial College London and the Royal Brompton Hospital, said: "This new guideline provides a platform to help us understand severe asthma and how to treat it. As the evidence available for the field of severe asthma is only just emerging, we must take the opportunity to build on this knowledge and increase our efforts to ultimately provide personalized medicine to people with this condition."

Guy Brusselle, Guidelines Director for the European Respiratory Society, said: "Although severe asthma cases are a relatively smaller proportion of all asthma cases, people with this condition can experience breathlessness all the time, as well as frequent and severe asthma attacks, requiring hospitalization. This seriously impairs quality of life for an individual and represents a huge financial burden for society. These new guidelines provide recommendations for an approach to diagnose and treat the condition and it's our responsibility to now ensure they are implemented for the benefit of patients."


Story Source:

The above story is based on materials provided by European Lung Foundation. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. F. Chung, S. E. Wenzel, J. L. Brozek, A. Bush, M. Castro, P. J. Sterk, I. M. Adcock, E. D. Bateman, E. H. Bel, E. R. Bleecker, L.-P. Boulet, C. Brightling, P. Chanez, S.-E. Dahlen, R. Djukanovic, U. Frey, M. Gaga, P. Gibson, Q. Hamid, N. N. Jajour, T. Mauad, R. L. Sorkness, W. G. Teague. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. European Respiratory Journal, 2013; DOI: 10.1183/09031936.00202013

Cite This Page:

European Lung Foundation. "New guidelines for severe asthma provide updated treatment, definition of disease." ScienceDaily. ScienceDaily, 12 December 2013. <www.sciencedaily.com/releases/2013/12/131212100150.htm>.
European Lung Foundation. (2013, December 12). New guidelines for severe asthma provide updated treatment, definition of disease. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2013/12/131212100150.htm
European Lung Foundation. "New guidelines for severe asthma provide updated treatment, definition of disease." ScienceDaily. www.sciencedaily.com/releases/2013/12/131212100150.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins