Featured Research

from universities, journals, and other organizations

EGF receptor ecto-domain mutations: When to screen and when not to screen

Date:
December 17, 2013
Source:
Landes Bioscience
Summary:
The epidermal growth factor receptor (EGFR) is expressed in normal colonic cells and is activated by specific peptide growth factors that regulate cell proliferation, survival and differentiation. Increased expression and activation of the EGFR has been observed in the majority of colorectal carcinoma, suggesting that the EGFR pathway plays an important role in colon carcinogenesis.

The epidermal growth factor receptor (EGFR) is expressed in normal colonic cells and is activated by specific peptide growth factors that regulate cell proliferation, survival and differentiation. Increased expression and activation of the EGFR has been observed in the majority of colorectal carcinoma (CRC), suggesting that the EGFR pathway plays an important role in colon carcinogenesis.

The monoclonal antibodies cetuximab and panitumumab are capable of blocking EGFR activity and have shown clinical activity in patients with metastatic CRC (mCRC). However, the efficacy of these agents is significantly limited by mechanisms of intrinsic and acquired resistance. In this respect, the S492R mutation of the extracellular domain of the EGFR is a peculiar mechanism of acquired resistance that limits the binding of cetuximab, but not panitumumab, to the EGFR.

This study is the first to demonstrate that the S492R EGFR ectodomain mutation is never present in patients that have not been exposed to EGFR monoclonal antibodies. In particular, a large cohort (505 patients) of KRAS exon 2 wild type mCRC cases, potential candidates for treatment with cetuximab, were screened to test for the S492R EGFR mutation; a sensitive test that failed to identify any mutation.

These findings suggest that the S492R EGFR mutation is not involved in primary resistance to cetuximab in CRC and have important consequences on the molecular assessment of mCRC patients. Based on these findings patients with mCRC should not be routinely screened for the S492R mutation prior therapy with cetuximab.


Story Source:

The above story is based on materials provided by Landes Bioscience. Note: Materials may be edited for content and length.


Journal Reference:

  1. Claudia Esposito, Anna Maria Rachiglio, Maria Libera La Porta, Alessandra Sacco, Cristin Roma, Alessia Iannaccone, Fabiana Tatangelo, Laura Forgione, Raffaella Pasquale, Americo Barbaro, Gerardo Botti, Fortunato Ciardiello, Nicola Normanno. The S492R EGFR ectodomain mutation is never detected in KRAS wild type colorectal carcinoma before exposure to EGFR monoclonal antibodies. Cancer Biology & Therapy, 2013; 14 (12) DOI: 10.4161/cbt.26340

Cite This Page:

Landes Bioscience. "EGF receptor ecto-domain mutations: When to screen and when not to screen." ScienceDaily. ScienceDaily, 17 December 2013. <www.sciencedaily.com/releases/2013/12/131217171004.htm>.
Landes Bioscience. (2013, December 17). EGF receptor ecto-domain mutations: When to screen and when not to screen. ScienceDaily. Retrieved April 25, 2014 from www.sciencedaily.com/releases/2013/12/131217171004.htm
Landes Bioscience. "EGF receptor ecto-domain mutations: When to screen and when not to screen." ScienceDaily. www.sciencedaily.com/releases/2013/12/131217171004.htm (accessed April 25, 2014).

Share This



More Health & Medicine News

Friday, April 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
Blood From World's Oldest Woman Suggests Life Limit

Blood From World's Oldest Woman Suggests Life Limit

Newsy (Apr. 24, 2014) Scientists say for the extremely elderly, their stem cells might reach a state of exhaustion. This could limit one's life span. Video provided by Newsy
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins