Featured Research

from universities, journals, and other organizations

Researchers identify genetic marker of resistance to key malaria drug

Date:
December 18, 2013
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
An international team of researchers has discovered a way to identify, at a molecular level, malaria-causing Plasmodium falciparum parasites that are resistant to artemisinin, the key drug for treating this disease.

An international team of researchers has discovered a way to identify, at a molecular level, malaria-causing Plasmodium falciparum parasites that are resistant to artemisinin, the key drug for treating this disease. The research team, which included scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, published their findings today in the journal Nature.

According to the World Health Organization, an estimated 627,000 people died of malaria in 2012. Artemisinin, in combination with other drugs, is the first-line treatment for malaria. In recent years, however, artemisinin-resistant malaria has appeared in patients in Southeast Asia, and researchers have begun exploring ways to maintain the drug's effectiveness. To monitor the spread of artemisinin resistance, scientists need a way to identify drug-resistant, malaria-causing parasites, the study authors write. They sought to fill this need by sequencing the complete genetic information of a laboratory-generated strain of artemisinin-resistant P. falciparum, and of both resistant and susceptible parasites found in nature in Cambodia, and then searching for links between the parasites' genes and resistance to the drug.

The researchers found that P. falciparum parasites with a mutant version of a gene called K13-propeller were more likely to survive exposure to artemisinin in the laboratory setting. Similarly, in malaria patients treated with the drug, parasites with the genetic mutation were eliminated more slowly. Further, they found that the geographical distribution of the genetic mutation in parasites in western Cambodia tracked with the spread of resistance among malaria patients in that region in recent years. Taken together, these results suggest that the mutant version of K13-propeller is associated with artemisinin resistance, according to the researchers. Future research will examine how the mutation causes resistance and explore whether this association extends to other regions of the world.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Frédéric Ariey, Benoit Witkowski, Chanaki Amaratunga, Johann Beghain, Anne-Claire Langlois, Nimol Khim, Saorin Kim, Valentine Duru, Christiane Bouchier, Laurence Ma, Pharath Lim, Rithea Leang, Socheat Duong, Sokunthea Sreng, Seila Suon, Char Meng Chuor, Denis Mey Bout, Sandie Ménard, William O. Rogers, Blaise Genton, Thierry Fandeur, Olivo Miotto, Pascal Ringwald, Jacques Le Bras, Antoine Berry, Jean-Christophe Barale, Rick M. Fairhurst, Françoise Benoit-Vical, Odile Mercereau-Puijalon, Didier Ménard. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature, 2013; DOI: 10.1038/nature12876

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Researchers identify genetic marker of resistance to key malaria drug." ScienceDaily. ScienceDaily, 18 December 2013. <www.sciencedaily.com/releases/2013/12/131218133704.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2013, December 18). Researchers identify genetic marker of resistance to key malaria drug. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2013/12/131218133704.htm
NIH/National Institute of Allergy and Infectious Diseases. "Researchers identify genetic marker of resistance to key malaria drug." ScienceDaily. www.sciencedaily.com/releases/2013/12/131218133704.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins