Featured Research

from universities, journals, and other organizations

Express yourself: Novel approach to study how genetic differences affect gene expression

Date:
January 9, 2014
Source:
University of California, Los Angeles (UCLA), Health Sciences
Summary:
Researchers have developed a novel approach to study how the differences between individuals affect how strongly genes are expressed, or translated into the proteins that do the actual work in cells.

Each individual carries a unique version of the human genome. Genetic differences can influence traits such as height, weight and vulnerability to disease, but precisely what these genetic variants are and how they exercise their impact is mostly unknown. UCLA researchers have now developed a novel approach to study the ways in which these individual differences affect how strongly certain genes are "expressed" -- that is, how they are translated into the proteins that do the actual work in cells.

Related Articles


Using different strains of a yeast called Saccharomyces cerevisiae, a single-celled fungus, they studied hundreds of thousands of genetically different yeast cells -- orders of magnitude more than previously examined -- making their approach statistically powerful and significantly more revealing about how genetic differences influence gene expression.

They also directly studied protein levels, an approach that differed from earlier work, which focused on levels of messenger RNA (mRNA), the intermediate molecules that cells use to read genes and translate them into proteins. While mRNAs are easier to measure than proteins, their levels don't always correspond to protein levels.

The two-and-a-half-year study found that the protein expression of a typical gene is influenced by many more genetic variants than previously thought and that the effects of genetic differences on mRNA levels corresponded much more closely to the effects on protein expression than seen earlier. Additionally, there is a complex web of variants that affects a large fraction of the proteins in cells.

The work could shed light on the study of disease risk in humans, as genetic variants that influence disease often act by affecting the expression of genes. Clinical applications may eventually flow from a better understanding of the process of genetic variants and protein expression.


Story Source:

The above story is based on materials provided by University of California, Los Angeles (UCLA), Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Frank W. Albert, Sebastian Treusch, Arthur H. Shockley, Joshua S. Bloom, Leonid Kruglyak. Genetics of single-cell protein abundance variation in large yeast populations. Nature, 2014; DOI: 10.1038/nature12904

Cite This Page:

University of California, Los Angeles (UCLA), Health Sciences. "Express yourself: Novel approach to study how genetic differences affect gene expression." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109101746.htm>.
University of California, Los Angeles (UCLA), Health Sciences. (2014, January 9). Express yourself: Novel approach to study how genetic differences affect gene expression. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2014/01/140109101746.htm
University of California, Los Angeles (UCLA), Health Sciences. "Express yourself: Novel approach to study how genetic differences affect gene expression." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109101746.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Classic Hollywood Memorabilia Goes Under the Hammer

Classic Hollywood Memorabilia Goes Under the Hammer

Reuters - Entertainment Video Online (Nov. 26, 2014) The iconic piano from "Casablanca" and the Cowardly Lion suit from "The Wizard of Oz" fetch millions at auction. Sara Hemrajani reports. Video provided by Reuters
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Feast Your Eyes: Lamb Chop Sent Into Space from UK

Feast Your Eyes: Lamb Chop Sent Into Space from UK

Reuters - Light News Video Online (Nov. 25, 2014) Take a stab at this -- stunt video shows a lamb chop's journey from an east London restaurant over 30 kilometers into space. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins