Featured Research

from universities, journals, and other organizations

Express yourself: Novel approach to study how genetic differences affect gene expression

Date:
January 9, 2014
Source:
University of California, Los Angeles (UCLA), Health Sciences
Summary:
Researchers have developed a novel approach to study how the differences between individuals affect how strongly genes are expressed, or translated into the proteins that do the actual work in cells.

Each individual carries a unique version of the human genome. Genetic differences can influence traits such as height, weight and vulnerability to disease, but precisely what these genetic variants are and how they exercise their impact is mostly unknown. UCLA researchers have now developed a novel approach to study the ways in which these individual differences affect how strongly certain genes are "expressed" -- that is, how they are translated into the proteins that do the actual work in cells.

Related Articles


Using different strains of a yeast called Saccharomyces cerevisiae, a single-celled fungus, they studied hundreds of thousands of genetically different yeast cells -- orders of magnitude more than previously examined -- making their approach statistically powerful and significantly more revealing about how genetic differences influence gene expression.

They also directly studied protein levels, an approach that differed from earlier work, which focused on levels of messenger RNA (mRNA), the intermediate molecules that cells use to read genes and translate them into proteins. While mRNAs are easier to measure than proteins, their levels don't always correspond to protein levels.

The two-and-a-half-year study found that the protein expression of a typical gene is influenced by many more genetic variants than previously thought and that the effects of genetic differences on mRNA levels corresponded much more closely to the effects on protein expression than seen earlier. Additionally, there is a complex web of variants that affects a large fraction of the proteins in cells.

The work could shed light on the study of disease risk in humans, as genetic variants that influence disease often act by affecting the expression of genes. Clinical applications may eventually flow from a better understanding of the process of genetic variants and protein expression.


Story Source:

The above story is based on materials provided by University of California, Los Angeles (UCLA), Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Frank W. Albert, Sebastian Treusch, Arthur H. Shockley, Joshua S. Bloom, Leonid Kruglyak. Genetics of single-cell protein abundance variation in large yeast populations. Nature, 2014; DOI: 10.1038/nature12904

Cite This Page:

University of California, Los Angeles (UCLA), Health Sciences. "Express yourself: Novel approach to study how genetic differences affect gene expression." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109101746.htm>.
University of California, Los Angeles (UCLA), Health Sciences. (2014, January 9). Express yourself: Novel approach to study how genetic differences affect gene expression. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/01/140109101746.htm
University of California, Los Angeles (UCLA), Health Sciences. "Express yourself: Novel approach to study how genetic differences affect gene expression." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109101746.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins