Featured Research

from universities, journals, and other organizations

New clues to how bacteria evade antibiotics

Date:
January 9, 2014
Source:
Imperial College London
Summary:
Scientists have made an important advance in understanding how a subset of bacterial cells escape being killed by many antibiotics.

Scientists have made an important advance in understanding how a subset of bacterial cells escape being killed by many antibiotics.

Cells become "persisters" by entering a state in which they stop replicating and are able to tolerate antibiotics. Unlike antibiotic resistance, which arises because of genetic mutations and is passed on to later generations, this tolerant phase is only temporary, but it may contribute to the later development of resistance.

In a new study in the journal Science, researchers from the MRC Centre for Molecular Bacteriology and Infection at Imperial College London have succeeded in visualising persister cells in infected tissues for the first time, and have identified signals that lead to their formation.

Virtually all bacterial species form subpopulations of persisters that are tolerant to many antibiotics. Persisters are likely to be a cause of many recurrent infections, but little is known about how they arise.

The team developed a method for tracking single cells using a fluorescent protein produced by the bacteria. They showed that Salmonella, which causes gastroenteritis and typhoid fever, forms large numbers of non-replicating persisters after being engulfed by immune cells called macrophages. By adopting this non-replicating mode, Salmonella survives antibiotic treatment and lingers in the host, accounting for its ability to cause recurrent infections.

The researchers also identified factors produced by human cells that trigger bacteria to become persisters.

One of the lead authors, Dr Sophie Helaine, said: "We rely on antibiotics to defend us against common bacterial infections like tuberculosis, cystitis, tonsillitis and typhoid, but a few cells can escape treatment by becoming persisters, which allows the infection to come back. This is a big problem in itself, but it also makes it more likely that antibiotic resistance will arise and spread.

"Now we know the molecular pathways and mechanisms that lead to persister formation during infection, we can work on screening for new drugs to coax them out of this state so that they become vulnerable to antibiotics."

The other lead author, Professor David Holden, Director of the MRC Centre for Molecular Bacteriology and Infection at Imperial College London, said: "One of the most striking findings in this work is that conditions inside immune cells activate two different responses from Salmonella, causing some bacteria to replicate and others to enter a non-replicating persister state. Activating these two responses together is likely to be an important mechanism by which Salmonella survives during infection."

The research was supported by an Imperial College London Junior Research Fellowship, the Wellcome Trust and the Medical Research Council.


Story Source:

The above story is based on materials provided by Imperial College London. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Helaine, A. M. Cheverton, K. G. Watson, L. M. Faure, S. A. Matthews, D. W. Holden. Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters. Science, 2014; 343 (6167): 204 DOI: 10.1126/science.1244705

Cite This Page:

Imperial College London. "New clues to how bacteria evade antibiotics." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109143715.htm>.
Imperial College London. (2014, January 9). New clues to how bacteria evade antibiotics. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2014/01/140109143715.htm
Imperial College London. "New clues to how bacteria evade antibiotics." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109143715.htm (accessed July 25, 2014).

Share This




More Plants & Animals News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Dogs Appear To Become Jealous Of Owners' Attention

Dogs Appear To Become Jealous Of Owners' Attention

Newsy (July 23, 2014) A U.C. San Diego researcher says jealousy isn't just a human trait, and dogs aren't the best at sharing the attention of humans with other dogs. Video provided by Newsy
Powered by NewsLook.com
Professor Creates Site Revealing Where People's Cats Live

Professor Creates Site Revealing Where People's Cats Live

Newsy (July 23, 2014) ​It's called I Know Where Your Cat Lives, and you can keep hitting the "Random Cat" button to find more real cats all over the world. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins