Featured Research

from universities, journals, and other organizations

Novel biomarker approach suggests new avenues to improve schizophrenia disease management

Date:
January 9, 2014
Source:
Virginia Commonwealth University
Summary:
Environmental effects of events such as oxygen deprivation and infections may be preserved as markers in blood that are associated to schizophrenia, according to an international study.

Environmental effects of events such as oxygen deprivation and infections may be preserved as markers in blood that are associated to schizophrenia, according to an international study led by the Virginia Commonwealth University School of Pharmacy's Center for Biomarker Research and Personalized Medicine.

"These markers, possibly from as early as embryonic development or birth, could be of considerable clinical importance as they could allow for identification of distinct schizophrenia subtypes or help predict treatment responses," said Karolina Aberg, Ph.D., associate director of the Center for Biomarker Research and Personalized Medicine and first author of the study.

Schizophrenia is a devastating psychiatric disorder. Although there is strong support for the involvement of DNA sequence variation in the development of the disorder, other factors such as environmental influences are also likely to play a major role.

The research team performed one of the first large-scale, methylome-wide association studies (MWAS) of schizophrenia, as detailed online in the January issue of JAMA Psychiatry, the JAMA Network journal.

"Methylation is a specific modification to the DNA molecule that could potentially reflect environmental events," said Edwin van den Oord, Ph.D., director of the Center for Biomarker Research and Personalized Medicine and senior author of the study. "Therefore, DNA methylation studies are very promising complements to traditional genetic studies that potentially can give us a deeper understanding of the schizophrenia disease etiology."

In this study, researchers investigated approximately 27 million DNA methylation markings in blood samples from 1,497 schizophrenia cases and controls.

This methylome-wide screening was performed by extracting the methylated portion of the genome and then investigating this portion with massively parallel next-generation sequencing. To ensure that the findings from this screening were not false findings caused, for example, by method-specific artifacts or statistical errors, researchers used a different technology to follow up the critical top findings in independent subjects who were not part of the initial screening step.

The study identified 139 highly significant methylation sites. Many of the replicating markings could be linked to hypoxia, immune response and neuronal differentiation, which are risk factors previously associated with schizophrenia development.


Story Source:

The above story is based on materials provided by Virginia Commonwealth University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Karolina A. Aberg, Joseph L. McClay, Srilaxmi Nerella, Shaunna Clark, Gaurav Kumar, Wenan Chen, Amit N. Khachane, Linying Xie, Alexandra Hudson, Guimin Gao, Aki Harada, Christina M. Hultman, Patrick F. Sullivan, Patrik K. E. Magnusson, Edwin J. C. G. van den Oord. Methylome-Wide Association Study of Schizophrenia. JAMA Psychiatry, 2014; DOI: 10.1001/jamapsychiatry.2013.3730

Cite This Page:

Virginia Commonwealth University. "Novel biomarker approach suggests new avenues to improve schizophrenia disease management." ScienceDaily. ScienceDaily, 9 January 2014. <www.sciencedaily.com/releases/2014/01/140109180423.htm>.
Virginia Commonwealth University. (2014, January 9). Novel biomarker approach suggests new avenues to improve schizophrenia disease management. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2014/01/140109180423.htm
Virginia Commonwealth University. "Novel biomarker approach suggests new avenues to improve schizophrenia disease management." ScienceDaily. www.sciencedaily.com/releases/2014/01/140109180423.htm (accessed September 2, 2014).

Share This




More Mind & Brain News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com
Young Entrepreneurs Get $100,000, If They Quit School

Young Entrepreneurs Get $100,000, If They Quit School

AFP (Aug. 29, 2014) Twenty college-age students are getting 100,000 dollars from a Silicon Valley leader and a chance to live in San Francisco in order to work on the start-up project of their dreams, but they have to quit school first. Duration: 02:20 Video provided by AFP
Powered by NewsLook.com
Baby Babbling Might Lead To Faster Language Development

Baby Babbling Might Lead To Faster Language Development

Newsy (Aug. 29, 2014) A new study suggests babies develop language skills more quickly if their parents imitate the babies' sounds and expressions and talk to them often. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins