Featured Research

from universities, journals, and other organizations

Potential for new tests in long-term diabetes complications

Date:
January 14, 2014
Source:
Johns Hopkins Bloomberg School of Public Health
Summary:
Monitoring glucose levels is imperative for diabetes patients, but for some the standard Hemoglobin A1c (HbA1c) test is not valid. Researchers have determined that the fructosamine tests and a novel assay for glycated albumin may be useful for predicting complications related to diabetes.

Monitoring glucose levels is imperative for diabetes patients, but for some the standard Hemoglobin A1c (HbA1c) test is not valid. Researchers from Johns Hopkins University, the University of Wisconsin, and the University of Minnesota have determined that the fructosamine tests and a novel assay for glycated albumin may be useful for predicting complications related to diabetes. The results will be published in the latest edition of The Lancet Diabetes & Endocrinology.

HbA1c, which is also used to diagnose diabetes, reflects exposure to glucose in the blood over the previous 2-3 months. However, this test will not work in patients with anemia, kidney disease, hemoglobinopathies, HIV, and other conditions. The study measured HbA1c, fructosamine and glycated albumin in blood samples from over 12,000 participants in the Atherosclerosis Risk in Communities (ARIC) Study. The ARIC Study is a community-based cohort of persons from Washington County, MD; Jackson, MS; Forsyth County, NC; and suburban Minneapolis, MN who have been followed for clinical outcomes since 1987. Fructosamine is approved for clinical use in the United States but rarely used. The glycated albumin test is widely used in Japan but not approved for use in the United States. A major barrier to using these non-traditional markers is that they have not been related to the clinical outcomes of diabetes or compared to HbA1c.

"We compared the associations of HbA1c, fructosamine, and glycated albumin with two of the most important clinical outcomes related to diabetes: retinopathy (eye disease) and kidney disease," notes lead author Elizabeth Selvin, PhD, MPH, associate professor, Johns Hopkins Bloomberg School of Public Health. "We found that fructosamine and glycated albumin were strongly associated with retinopathy and kidney disease. [T]hese associations were similar to those observed for HbA1c with these outcomes."

The results of the study suggest that fructosamine and glycated albumin may be useful substitutes for monitoring glucose control in patients with diabetes when HbA1c is not available or not valid. Because fructosamine and glycated albumin are measures of short-term (2-4 week) glucose control and change more rapidly than HbA1c, they could also be useful for monitoring changes in diabetes treatments.

"Further studies are needed to understand the value of these tests in the clinic," Selvin added.


Story Source:

The above story is based on materials provided by Johns Hopkins Bloomberg School of Public Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Elizabeth Selvin, Andreea M Rawlings, Morgan Grams, Ronald Klein, A Richey Sharrett, Michael Steffes, Josef Coresh. Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. The Lancet Diabetes & Endocrinology, 2014; DOI: 10.1016/S2213-8587(13)70199-2

Cite This Page:

Johns Hopkins Bloomberg School of Public Health. "Potential for new tests in long-term diabetes complications." ScienceDaily. ScienceDaily, 14 January 2014. <www.sciencedaily.com/releases/2014/01/140114202651.htm>.
Johns Hopkins Bloomberg School of Public Health. (2014, January 14). Potential for new tests in long-term diabetes complications. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2014/01/140114202651.htm
Johns Hopkins Bloomberg School of Public Health. "Potential for new tests in long-term diabetes complications." ScienceDaily. www.sciencedaily.com/releases/2014/01/140114202651.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins