Featured Research

from universities, journals, and other organizations

Chronic intestinal damage raises hip-fracture rate in celiac disease patients

Date:
January 16, 2014
Source:
Endocrine Society
Summary:
Celiac disease patients who experience chronic damage in the small intestine may be more likely to break a hip than those whose intestinal tissues have begun healing, according to new research.

Celiac disease patients who experience chronic damage in the small intestine may be more likely to break a hip than those whose intestinal tissues have begun healing, according to new research accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Celiac disease is an autoimmune condition that affects about 1 percent of the U.S. population. When people with the condition eat gluten -- a protein found in grains like wheat -- it triggers an immune response in the small intestine. Patients with this condition face a higher risk of breaking a bone, but studies have reached contradictory conclusions about whether the fracture risk remains elevated long after the disease is diagnosed and managed with a gluten-free diet.

"We believe that giving the mucous membrane -- the moist tissue lining the small intestine -- a chance to heal can lower the risk of complications, including bone fractures, in celiac patients," said one of the study's authors, Jonas F. Ludvigsson, PhD, MD, of Karolinska University Hospital and Karolinska Institute in Stockholm, Sweden. "Our research confirmed that patients had a higher rate of hip fractures when tissue damage persisted over time. Sticking to a gluten-free diet is crucial for minimizing tissue damage and reducing the risk of a serious fracture that could cause other complications."

The cohort study analyzed tissue samples from 7,146 Swedes who were diagnosed with celiac disease from July 1969 to February 2008 and received follow-up biopsies within five years of diagnosis. Researchers examined intestinal tissue from the biopsies to determine the level of damage. Among this population, 43 percent had persistent villous atrophy where the intestinal tissue did not heal. (The villi are tiny structures that project from the lining of the small intestine.)

Researchers analyzed patient records to determine how many had broken bones. Patients were monitored for a median of 10.3 years after being diagnosed with celiac disease. The study found that people who had persistent tissue damage were more likely to break a hip. All patients faced a similar risk close to the time of the follow-up biopsy. The group with persistent tissue damage had a heightened risk of hip fracture beginning five years after the follow-up biopsy, indicating a higher long-term risk.

"Physicians have debated whether people with celiac disease actually benefit from a follow-up biopsy to determine the level of tissue healing taking place," said one of the study's authors, Benjamin Lebwohl, MD, MS, of the Celiac Disease Center at Columbia University Medical Center in New York. "These findings suggest that a follow-up biopsy can be useful for predicting complications down the road."


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jonas F. Ludvigsson, PhD, MD et al. Persistent Mucosal Damage and Risk of Fracture in Celiac Disease. JCEM, February 2014

Cite This Page:

Endocrine Society. "Chronic intestinal damage raises hip-fracture rate in celiac disease patients." ScienceDaily. ScienceDaily, 16 January 2014. <www.sciencedaily.com/releases/2014/01/140116144643.htm>.
Endocrine Society. (2014, January 16). Chronic intestinal damage raises hip-fracture rate in celiac disease patients. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/01/140116144643.htm
Endocrine Society. "Chronic intestinal damage raises hip-fracture rate in celiac disease patients." ScienceDaily. www.sciencedaily.com/releases/2014/01/140116144643.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins