Featured Research

from universities, journals, and other organizations

Protecting the skin from sun exposure

Date:
January 27, 2014
Source:
The Rockefeller University Press
Summary:
The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. Researchers provide new insight into the molecular pathway underlying this process.

This is a proposed model for the molecular pathway that allows human skin to detect and respond to the UV radiation in sunlight. Understanding this pathway is critical to developing better methods of skin protection.
Credit: Bellono et al., 2014

The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen, and long-term exposure to UVR can lead to skin cancer and premature aging of the skin. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. A study in The Journal of General Physiology provides new insight into the molecular pathway underlying this process.

Skin cells called melanocytes respond to UVR by increasing the skin's pigmentation, a protective mechanism otherwise known as tanning. But the exact details of the early stages of the response to UVR are poorly understood. Now, researchers from Brown University have identified key elements of the UVR-activated pathway in skin.

The researchers identified a specific protein involved in mediating the skin's response to UVR as well as some downstream elements in the pathway. Intriguingly, their data suggest that, in melanocytes responding to UVR, the signal transduction cascade (the process by which an external stimulus leads to a response inside a cell) resembles a light-activated pathway in the eye.

More research is needed to identify other key players in this newly characterized UVR response pathway. As these remaining gaps are filled, researchers can use the information to develop better methods for protecting the human skin from the damaging effects of sun exposure.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. W. Bellono, J. A. Najera, E. Oancea. UV light activates a Gq/11-coupled phototransduction pathway in human melanocytes. The Journal of General Physiology, 2014; 143 (2): 203 DOI: 10.1085/jgp.201311094

Cite This Page:

The Rockefeller University Press. "Protecting the skin from sun exposure." ScienceDaily. ScienceDaily, 27 January 2014. <www.sciencedaily.com/releases/2014/01/140127122146.htm>.
The Rockefeller University Press. (2014, January 27). Protecting the skin from sun exposure. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2014/01/140127122146.htm
The Rockefeller University Press. "Protecting the skin from sun exposure." ScienceDaily. www.sciencedaily.com/releases/2014/01/140127122146.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins