Featured Research

from universities, journals, and other organizations

Protecting the skin from sun exposure

Date:
January 27, 2014
Source:
The Rockefeller University Press
Summary:
The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. Researchers provide new insight into the molecular pathway underlying this process.

This is a proposed model for the molecular pathway that allows human skin to detect and respond to the UV radiation in sunlight. Understanding this pathway is critical to developing better methods of skin protection.
Credit: Bellono et al., 2014

The ultraviolet radiation (UVR) present in sunlight is the most common environmental carcinogen, and long-term exposure to UVR can lead to skin cancer and premature aging of the skin. To develop better methods of protection from the sun, we need to understand how the human skin detects and responds to UVR. A study in The Journal of General Physiology provides new insight into the molecular pathway underlying this process.

Skin cells called melanocytes respond to UVR by increasing the skin's pigmentation, a protective mechanism otherwise known as tanning. But the exact details of the early stages of the response to UVR are poorly understood. Now, researchers from Brown University have identified key elements of the UVR-activated pathway in skin.

The researchers identified a specific protein involved in mediating the skin's response to UVR as well as some downstream elements in the pathway. Intriguingly, their data suggest that, in melanocytes responding to UVR, the signal transduction cascade (the process by which an external stimulus leads to a response inside a cell) resembles a light-activated pathway in the eye.

More research is needed to identify other key players in this newly characterized UVR response pathway. As these remaining gaps are filled, researchers can use the information to develop better methods for protecting the human skin from the damaging effects of sun exposure.


Story Source:

The above story is based on materials provided by The Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. W. Bellono, J. A. Najera, E. Oancea. UV light activates a Gq/11-coupled phototransduction pathway in human melanocytes. The Journal of General Physiology, 2014; 143 (2): 203 DOI: 10.1085/jgp.201311094

Cite This Page:

The Rockefeller University Press. "Protecting the skin from sun exposure." ScienceDaily. ScienceDaily, 27 January 2014. <www.sciencedaily.com/releases/2014/01/140127122146.htm>.
The Rockefeller University Press. (2014, January 27). Protecting the skin from sun exposure. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2014/01/140127122146.htm
The Rockefeller University Press. "Protecting the skin from sun exposure." ScienceDaily. www.sciencedaily.com/releases/2014/01/140127122146.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
More People Diagnosed With TB In 2013, But There's Good News

More People Diagnosed With TB In 2013, But There's Good News

Newsy (Oct. 22, 2014) The World Health Organizations says TB numbers rose in 2013, but it's partly due to better detection and more survivors. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins