Featured Research

from universities, journals, and other organizations

Researchers find changes to protein SirT1

Date:
January 27, 2014
Source:
Boston University Medical Center
Summary:
Studies have suggested that the protein SirT1 may be protective in metabolic diseases and the effects of aging, and diminished SirT1 activity has been reported in various disease models including diabetes and metabolic syndrome. Maintaining a normal level of this protein may be effective in preventing obesity- and age-related diseases.

Researchers find changes to protein SirT1 can prevent excess metabolic stress associated with obesity, diabetes and aging.

Studies have suggested that the protein SirT1 may be protective in metabolic diseases and the effects of aging, and diminished SirT1 activity has been reported in various disease models including diabetes and metabolic syndrome. Maintaining a normal level of this protein may be effective in preventing obesity- and age-related diseases.

Metabolic stress caused by obesity, diabetes and aging increases a small molecule, glutathione that reacts with SirT1, inhibiting its activity. In a recent paper published online in the Journal of Biological Chemistry, Boston University School of Medicine (BUSM) researchers have demonstrated that by changing three of the amino acids on SirT1 they could produce a "super-sirt" which functioned normally despite the metabolic stress.

"In the process of preventing the effects of the stress occasioned by metabolic excess typical of obesity, diabetes and aging, the enzyme function of SirT1 can be destroyed by the very metabolic stress it is trying to overcome," says Richard Cohen, MD, professor of medicine and director of the section of vascular biology at BUSM. "This study establishes that stresses associated with excess metabolism can be circumvented by changing the protein, or by preventing the glutathione reaction with the protein."


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Shao, J. L. Fry, J. Han, X. Hou, D. R. Pimentel, R. Matsui, R. A. Cohen, M. M. Bachschmid. A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M113.520403

Cite This Page:

Boston University Medical Center. "Researchers find changes to protein SirT1." ScienceDaily. ScienceDaily, 27 January 2014. <www.sciencedaily.com/releases/2014/01/140127122827.htm>.
Boston University Medical Center. (2014, January 27). Researchers find changes to protein SirT1. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2014/01/140127122827.htm
Boston University Medical Center. "Researchers find changes to protein SirT1." ScienceDaily. www.sciencedaily.com/releases/2014/01/140127122827.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Uganda on Alert for Ebola but No Confirmed Cases

Uganda on Alert for Ebola but No Confirmed Cases

AFP (July 31, 2014) Uganda's health minister said on Thursday that there are no confirmed cases of Ebola in the country, but that it remained on alert for cases of the deadly virus. Uganda has suffered Ebola outbreaks in the past, most recently in 2012. Duration: 00:59 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins