Featured Research

from universities, journals, and other organizations

Cell division finding could boost understanding of cancer

Date:
February 3, 2014
Source:
University of Edinburgh
Summary:
New insights into how the cells in our bodies divide could improve our knowledge of a condition linked to cancer, a study suggests.

Errors in the cell division process -- which allows us to grow and stay healthy -- can lead to a genetic disorder called aneuploidy, which is also associated with birth defects and infertility.

Researchers at the University of Edinburgh have pinpointed the key role played by a protein in ensuring that cells separate correctly.

DNA duplication

During cell division, chromosomes containing our DNA duplicate and then separate to form two identical copies of the original cell.

Aneuploidy arises when chromosome pairs fail to separate properly.

Scientists say that a protein -- called shugoshin -- serves two important functions.

It recruits other parts of the cell which are needed for chromosome separation and enables an in-built error correction system to monitor cells as they divide.

Cell behavior

Researchers studied the effect that disabling shugoshin had on cell division in yeast.

The team found that in the absence of a working shugoshin protein, cells were more likely to contain abnormal numbers of chromosomes.

Cell division in yeast is very similar to that of humans, making it an excellent model in which to study the role that shugoshin plays in preventing aneuploidy in people.

The study, published in the journal eLife, was funded by the Wellcome Trust, the European Molecular Biology Organisation, the Scottish Universities Life Sciences Alliance and the Darwin Trust of Edinburgh.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. F. Verzijlbergen, O. O. Nerusheva, D. Kelly, A. Kerr, D. Clift, F. de Lima Alves, J. Rappsilber, A. L. Marston. Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere. eLife, 2014; 3 (0): e01374 DOI: 10.7554/eLife.01374

Cite This Page:

University of Edinburgh. "Cell division finding could boost understanding of cancer." ScienceDaily. ScienceDaily, 3 February 2014. <www.sciencedaily.com/releases/2014/02/140203191812.htm>.
University of Edinburgh. (2014, February 3). Cell division finding could boost understanding of cancer. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2014/02/140203191812.htm
University of Edinburgh. "Cell division finding could boost understanding of cancer." ScienceDaily. www.sciencedaily.com/releases/2014/02/140203191812.htm (accessed April 16, 2014).

Share This



More Plants & Animals News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Change of Diet Helps Crocodile Business

Change of Diet Helps Crocodile Business

Reuters - Business Video Online (Apr. 16, 2014) Crocodile farming has been a challenge in Zimbabwe in recent years do the economic collapse and the financial crisis. But as Ciara Sutton reports one of Europe's biggest suppliers of skins to the luxury market has come up with an unusual survival strategy - vegetarian food. Video provided by Reuters
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
In Washington, a Push to Sterilize Stray Cats

In Washington, a Push to Sterilize Stray Cats

AFP (Apr. 14, 2014) To curb the growing numbers of feral cats in the US capital, the Washington Humane Society is encouraging residents to set traps and bring the animals to a sterilization clinic, after which they are released.. Duration: 02:29 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins