Featured Research

from universities, journals, and other organizations

Existing medicines show promise for treating stomach, bowel cancer

Date:
February 4, 2014
Source:
Walter and Eliza Hall Institute
Summary:
Stomach and bowel cancer, two of the most common cancers worldwide, could be treated with a class of medicines that are currently used to treat a blood disorder, a research team has discovered.

Dr. Emma Stuart has discovered that existing medications could be used to treat certain types of bowel and stomach cancers.
Credit: Walter and Eliza Hall Institute

Stomach and bowel cancer, two of the most common cancers worldwide, could be treated with a class of medicines that are currently used to treat a blood disorder, a Melbourne research team has discovered.

The finding, in preclinical models, that medicines called 'JAK inhibitors' reduce the growth of inflammation-associated stomach and bowel cancer provides the first evidence supporting their use in treating these cancers.

JAK inhibitors are currently used to treat the cancer-like condition myelofibrosis, and are being investigated in clinical trials for the treatment of conditions including leukaemia, lymphoma, lupus and rheumatoid arthritis.

Dr Emma Stuart, Dr Tracy Putoczki and Associate Professor Matthias Ernst from the Walter and Eliza Hall Institute made the discovery with colleagues while at the Melbourne-Parkville Branch of the Ludwig Institute for Cancer Research. Associate Professor Ernst is also currently a Ludwig Member. Their findings have been published in the journal Molecular Cancer Therapeutics.

Dr Stuart said the discovery stemmed from the research team's long interest in the links between inflammation and cancers of the digestive tract. "Recently we have begun to unravel the complex signaling that occurs in inflamed tissues, such as when a person has a stomach ulcer or suffers from inflammatory bowel disease, and how this drives cancer development," she said.

"By understanding the molecules that are involved in promoting the survival and growth of cancer cells, we have been able to identify which of these molecules can be targeted with potential anti-cancer treatments. In this case, we determined that proteins called JAKs are involved in cancer formation in the stomach and bowel. It was exciting to discover that when JAKs were blocked with existing medications (JAK inhibitors), bowel and stomach cancer growth in experimental models was slowed, and many of the cancer cells were killed," Dr Stuart said.

Associate Professor Ernst said the findings were significant as JAK inhibitors were already available and had shown success in clinical trials, particularly for treating cancer-like blood conditions.

"Our team's research has uncovered several proteins that could be valuable targets in treating cancers of the digestive tract," he said. "The reason this discovery is particularly exciting is clinical trials have already shown that JAK proteins can be safely and successfully inhibited in patients. We hope this will expedite bringing our research to possible clinical trials that may improve the outlook for people with stomach and bowel cancer,"Associate Professor Ernst said.


Story Source:

The above story is based on materials provided by Walter and Eliza Hall Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Stuart, M. Buchert, T. Putoczki, S. Thiem, R. Farid, J. Elzer, D. Huszar, P. M. Waring, T. J. Phesse, M. Ernst. Therapeutic Inhibition of Jak Activity Inhibits Progression of Gastrointestinal Tumors in Mice. Molecular Cancer Therapeutics, 2014; DOI: 10.1158/1535-7163.MCT-13-0583-T

Cite This Page:

Walter and Eliza Hall Institute. "Existing medicines show promise for treating stomach, bowel cancer." ScienceDaily. ScienceDaily, 4 February 2014. <www.sciencedaily.com/releases/2014/02/140204101934.htm>.
Walter and Eliza Hall Institute. (2014, February 4). Existing medicines show promise for treating stomach, bowel cancer. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/02/140204101934.htm
Walter and Eliza Hall Institute. "Existing medicines show promise for treating stomach, bowel cancer." ScienceDaily. www.sciencedaily.com/releases/2014/02/140204101934.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins