Featured Research

from universities, journals, and other organizations

Existing medicines show promise for treating stomach, bowel cancer

Date:
February 4, 2014
Source:
Walter and Eliza Hall Institute
Summary:
Stomach and bowel cancer, two of the most common cancers worldwide, could be treated with a class of medicines that are currently used to treat a blood disorder, a research team has discovered.

Dr. Emma Stuart has discovered that existing medications could be used to treat certain types of bowel and stomach cancers.
Credit: Walter and Eliza Hall Institute

Stomach and bowel cancer, two of the most common cancers worldwide, could be treated with a class of medicines that are currently used to treat a blood disorder, a Melbourne research team has discovered.

Related Articles


The finding, in preclinical models, that medicines called 'JAK inhibitors' reduce the growth of inflammation-associated stomach and bowel cancer provides the first evidence supporting their use in treating these cancers.

JAK inhibitors are currently used to treat the cancer-like condition myelofibrosis, and are being investigated in clinical trials for the treatment of conditions including leukaemia, lymphoma, lupus and rheumatoid arthritis.

Dr Emma Stuart, Dr Tracy Putoczki and Associate Professor Matthias Ernst from the Walter and Eliza Hall Institute made the discovery with colleagues while at the Melbourne-Parkville Branch of the Ludwig Institute for Cancer Research. Associate Professor Ernst is also currently a Ludwig Member. Their findings have been published in the journal Molecular Cancer Therapeutics.

Dr Stuart said the discovery stemmed from the research team's long interest in the links between inflammation and cancers of the digestive tract. "Recently we have begun to unravel the complex signaling that occurs in inflamed tissues, such as when a person has a stomach ulcer or suffers from inflammatory bowel disease, and how this drives cancer development," she said.

"By understanding the molecules that are involved in promoting the survival and growth of cancer cells, we have been able to identify which of these molecules can be targeted with potential anti-cancer treatments. In this case, we determined that proteins called JAKs are involved in cancer formation in the stomach and bowel. It was exciting to discover that when JAKs were blocked with existing medications (JAK inhibitors), bowel and stomach cancer growth in experimental models was slowed, and many of the cancer cells were killed," Dr Stuart said.

Associate Professor Ernst said the findings were significant as JAK inhibitors were already available and had shown success in clinical trials, particularly for treating cancer-like blood conditions.

"Our team's research has uncovered several proteins that could be valuable targets in treating cancers of the digestive tract," he said. "The reason this discovery is particularly exciting is clinical trials have already shown that JAK proteins can be safely and successfully inhibited in patients. We hope this will expedite bringing our research to possible clinical trials that may improve the outlook for people with stomach and bowel cancer,"Associate Professor Ernst said.


Story Source:

The above story is based on materials provided by Walter and Eliza Hall Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Stuart, M. Buchert, T. Putoczki, S. Thiem, R. Farid, J. Elzer, D. Huszar, P. M. Waring, T. J. Phesse, M. Ernst. Therapeutic Inhibition of Jak Activity Inhibits Progression of Gastrointestinal Tumors in Mice. Molecular Cancer Therapeutics, 2014; DOI: 10.1158/1535-7163.MCT-13-0583-T

Cite This Page:

Walter and Eliza Hall Institute. "Existing medicines show promise for treating stomach, bowel cancer." ScienceDaily. ScienceDaily, 4 February 2014. <www.sciencedaily.com/releases/2014/02/140204101934.htm>.
Walter and Eliza Hall Institute. (2014, February 4). Existing medicines show promise for treating stomach, bowel cancer. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/02/140204101934.htm
Walter and Eliza Hall Institute. "Existing medicines show promise for treating stomach, bowel cancer." ScienceDaily. www.sciencedaily.com/releases/2014/02/140204101934.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins