Featured Research

from universities, journals, and other organizations

Fruit fly microRNA research offers clues to aging process

Date:
February 5, 2014
Source:
Rutgers University
Summary:
Diseases like Alzheimer's and Huntington's are often associated with aging, but the biological link between the two is less certain. Researchers are seeking insight into this connection by studying very small RNA molecules in the common fruit fly.

Diseases like Alzheimer's and Huntington's are often associated with aging, but the biological link between the two is less certain. Researchers at Rutgers University-Camden are seeking insight into this connection by studying very small RNA molecules in the common fruit fly.

"As the flies in our experiment age, we're able to detect specific patterns of microRNAs -- which help to regulate genes -- when they are bound to specific proteins," says Ammar Naqvi, a doctoral student in computational and integrative biology at Rutgers-Camden.

Naqvi, a Philadelphia resident, explains that microRNAs are connected to various developmental stages and disease states, and their proper modulation is required for the integrity and maintenance of cells.

The research is being done under the supervision of Andrey Grigoriev, a professor of biology at Rutgers-Camden, and in collaboration with a research team at the University of Pennsylvania. Computational and bioinformatics analysis for the project is performed at Rutgers-Camden.

In flies, microRNAs are "loaded" onto one of two protein complexes known as Ago1 or Ago2, which then guide it to repress gene expression. The team found that as fruit flies age, more microRNAs accumulate on the Ago2 protein complex, and therefore impact age-associated events in the flies.

"We were able to connect the two processes," Naqvi says. "Studies have shown that there is some change in the microRNA population with age, but no one was sure how they were partitioned with the protein complexes. We observed such partitioning and also an increase in neurodegeneration, which resulted in a shorter lifespan for these flies."

Grigoriev explains, "Neurodegeneration and aging go hand-in-hand, but we are the first to have shown the details of this change in regulation with aging. This tells us that there are different mechanisms of regulation in different stages of development. Is aging a byproduct of development? I cannot tell you. It's possible that this could be relevant for other diseases. That's what we want to find out."

The study was recently published in a leading journal in the field, Genes and Development.


Story Source:

The above story is based on materials provided by Rutgers University. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Abe, A. Naqvi, G.-J. Hendriks, V. Feltzin, Y. Zhu, A. Grigoriev, N. M. Bonini. Impact of age-associated increase in 2'-O-methylation of miRNAs on aging and neurodegeneration in Drosophila. Genes & Development, 2014; 28 (1): 44 DOI: 10.1101/gad.226654.113

Cite This Page:

Rutgers University. "Fruit fly microRNA research offers clues to aging process." ScienceDaily. ScienceDaily, 5 February 2014. <www.sciencedaily.com/releases/2014/02/140205165753.htm>.
Rutgers University. (2014, February 5). Fruit fly microRNA research offers clues to aging process. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/02/140205165753.htm
Rutgers University. "Fruit fly microRNA research offers clues to aging process." ScienceDaily. www.sciencedaily.com/releases/2014/02/140205165753.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins