Featured Research

from universities, journals, and other organizations

Heart attack research discovers new treatment target

Date:
February 10, 2014
Source:
Louisiana State University Health Sciences Center
Summary:
Research demonstrates for the first time cross-talk between two protective signaling molecules during a heart attack. By providing new and important information about the mechanisms involved in heart attacks and organ transplantation, the research identifies a potential new treatment target for heart disease.

Research led by David Lefer, PhD, Professor and Director of the Cardiovascular Center of Excellence at LSU Health Sciences Center New Orleans School of Medicine, demonstrates for the first time cross-talk between two protective signaling molecules during a heart attack. By providing new and important information about the mechanisms involved in heart attacks and organ transplantation, the research identifies a potential new treatment target for heart disease. The paper will be published in Proceedings of the National Academy of Sciences (PNAS) Online Early Edition the week of February 10, 2014.

Previous studies found that hydrogen sulfide protects cells from damage caused by a number of diseases, including cardiovascular, in a similar manner to that reported for another protective gas, nitric oxide. Though hydrogen sulfide and nitric oxide are biologically similar, it was thought that they protected cells via distinctly different mechanisms. The LSUHSC research team found that instead, they interact and "talk" to each other, and it is this interaction that produces the protective effect during heart attacks.

"We found that hydrogen sulfide regulates the body's production of nitric oxide which, in turn, protects the heart muscle against cell death," notes Dr. Lefer.

Working in a mouse model, the researchers discovered the interdependence between the two molecules. When an enzyme that produces hydrogen sulfide was absent, they found that the production and action of nitric oxide were greatly reduced, resulting in increased oxidative stress and more severe injury to the heart and liver from blocked blood flow as well as from the eventual restoration of blood flow.

"This study has far reaching implications for the development of novel treatments for cardiovascular disease," concludes Dr. Lefer. Although progress has been made, heart disease remains the leading cause of death in the United States. According to the American Heart Association, approximately every 34 seconds, 1 American has a coronary event, and approximately every 1 minute 23 seconds, an American will die of one.


Story Source:

The above story is based on materials provided by Louisiana State University Health Sciences Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. L. King, D. J. Polhemus, S. Bhushan, H. Otsuka, K. Kondo, C. K. Nicholson, J. M. Bradley, K. N. Islam, J. W. Calvert, Y.-X. Tao, T. R. Dugas, E. E. Kelley, J. W. Elrod, P. L. Huang, R. Wang, D. J. Lefer. Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1321871111

Cite This Page:

Louisiana State University Health Sciences Center. "Heart attack research discovers new treatment target." ScienceDaily. ScienceDaily, 10 February 2014. <www.sciencedaily.com/releases/2014/02/140210161330.htm>.
Louisiana State University Health Sciences Center. (2014, February 10). Heart attack research discovers new treatment target. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2014/02/140210161330.htm
Louisiana State University Health Sciences Center. "Heart attack research discovers new treatment target." ScienceDaily. www.sciencedaily.com/releases/2014/02/140210161330.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins