Featured Research

from universities, journals, and other organizations

Protein as promising target for treatment of anaplastic thyroid carcinoma

Date:
February 17, 2014
Source:
National University of Singapore
Summary:
Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer with a poor prognosis for which there is currently no effective treatment. Researchers have discovered for the first time that an epithelial basement membrane protein, called laminin-5 gamma-2 (LAMC2), has the potential to be an ideal target for the treatment of ATC. “Our findings provide a novel target for therapeutic research. We are now extending these investigations to additional types of frequent cancer subtypes," the authors note.

Anaplastic thyroid carcinoma (ATC) is an aggressive type of cancer with a poor prognosis for which there is currently no effective treatment. Researchers from the National University of Singapore (NUS) have discovered for the first time that an epithelial basement membrane protein, called laminin-5 gamma-2 (LAMC2), has the potential to be an ideal target for the treatment of ATC.

Led by Professor H. Phillip Koeffler, Senior Principal Investigator, and Dr Manoj Garg, Research Fellow, at the Cancer Science Institute of Singapore (CSI Singapore) at NUS, the team is also the first to demonstrate that effect of LAMC2 on cell growth, cell cycle, migration and invasion in ATC cells. This novel study was published in the Journal of Clinical Endocrinology and Metabolism last month.

Thyroid cancer is the most common cancer of the endocrine system. ATC are undifferentiated tumours of the thyroid follicular epithelium. This type of cancer has a poor prognosis due to their extremely aggressive nature and resistance to treatment. Overall survival from diagnosis is typically six months or less. As such, new therapeutic targets are needed to improve the clinical care of these patients.

The effect of LAMC2 on ATC cells

In their study, the researchers found that LAMC2 is over-expressed in a large cohort of ATC patient samples. Analysis of RNA data of ATC cells showed that LAMC2 is likely to play a role in the formation of tumours. They discovered that silencing of LAMC2 in ATC cells reduced their cell growth, migration and invasion. In addition, silencing of this protein impaired the cell cycle of ATC cells by arresting them at the growth phase to DNA replication phase, or the G1 to S phase transition, of their cell cycle.

At the same time, the study found that LAMC2 enhanced activation of growth signals through a cell surface protein called epidermal growth factor receptor (EGFR) in ATC cells. EGFR plays an important role in the behaviour of malignant cells in a variety of human tumours by increasing proliferation. Increased expression of epidermal growth factor and EGFR has been detected in 58 per cent to 87 per cent of ATC when compared with normal tissue. The researchers demonstrated that simultaneous silencing of LAMC2 combined with various ways of silencing EGFR effectively inhibited the growth of tumour cells.

The novel study provides a foundation for further investigation of LAMC2 as a promising target for developing novel therapeutic approaches for the treatment of ATC.

Said Prof Koeffler, "Our findings provide a novel target for therapeutic research. We are now extending these investigations to additional types of frequent cancer subtypes."


Story Source:

The above story is based on materials provided by National University of Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Manoj Garg, Deepika Kanojia, Ryoko Okamoto, Saket Jain, Vikas Madan, Wenwen Chien, Abhishek Sampath, Ling-Wen Ding, Meng Xuan, Jonathan W. Said, Ngan B. Doan, Li-Zhen Liu, Henry Yang, Sigal Gery, Glenn D. Braunstein, H. Phillip Koeffler. Laminin-5γ-2 (LAMC2) Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Progression, Migration, and Invasion by Modulating Signaling of EGFR. The Journal of Clinical Endocrinology & Metabolism, 2014; 99 (1): E62 DOI: 10.1210/jc.2013-2994

Cite This Page:

National University of Singapore. "Protein as promising target for treatment of anaplastic thyroid carcinoma." ScienceDaily. ScienceDaily, 17 February 2014. <www.sciencedaily.com/releases/2014/02/140217085242.htm>.
National University of Singapore. (2014, February 17). Protein as promising target for treatment of anaplastic thyroid carcinoma. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2014/02/140217085242.htm
National University of Singapore. "Protein as promising target for treatment of anaplastic thyroid carcinoma." ScienceDaily. www.sciencedaily.com/releases/2014/02/140217085242.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Obama Orders Military Response to Ebola

Obama Orders Military Response to Ebola

AP (Sep. 16, 2014) Calling the Ebola outbreak in West Africa a potential threat to global security, President Barack Obama is ordering 3,000 U.S. military personnel to the stricken region amid worries that the outbreak is spiraling out of control. (Sept. 16) Video provided by AP
Powered by NewsLook.com
UN: 20,000 Could Be Infected With Ebola by Year End

UN: 20,000 Could Be Infected With Ebola by Year End

AFP (Sep. 16, 2014) Nearly $1.0 billion dollars is needed to fight the Ebola outbreak raging in west Africa, the United Nations say, warning that 20,000 could be infected by year end. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins