Featured Research

from universities, journals, and other organizations

Eleven new genes affecting blood pressure discovered

Date:
February 20, 2014
Source:
Queen Mary, University of London
Summary:
11 new DNA sequence variants in genes influencing high blood pressure and heart disease have been discovered. Identifying the new genes contributes to our growing understanding of the biology of blood pressure and, researchers believe, will eventually influence the development of new treatments. More immediately the study highlights opportunities to investigate the use of existing drugs for cardiovascular diseases.

New research from Queen Mary University of London has discovered 11 new DNA sequence variants in genes influencing high blood pressure and heart disease.

Identifying the new genes contributes to our growing understanding of the biology of blood pressure and, researchers believe, will eventually influence the development of new treatments. More immediately the study highlights opportunities to investigate the use of existing drugs for cardiovascular diseases.

The large international study, published today in the American Journal of Human Genetics, examined the DNA of 87,736 individuals to discover genetic variants associated with blood pressure traits. Validation of these sequence variants was performed in a further 68,368 individuals. This analysis led to the identification of 11 new genes.

Worldwide, raised blood pressure is estimated to cause 7.5 million deaths, about 12.8% of the total of all deaths. Genes and lifestyle factors (e.g., salt intake and obesity) are both known to be important risk factors.

Patricia Munroe, Professor of Molecular Medicine at Queen Mary University of London, comments: "Discovering these new genetic variants provides vital insight into how the body regulates blood pressure. With further research, we are hopeful it could lead to the development of new treatments for treating blood pressure and heart disease -- a leading cause of death worldwide."

Michael Barnes, Director of Bioinformatics, Barts and The London NIHR Cardiovascular Biomedical Research Unit, Queen Mary University of London, comments:

"By highlighting several existing drugs that target proteins which influence blood pressure regulation, our study creates a very real opportunity to fast-track new therapies for hypertension into the clinic."


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vinicius Tragante, BrendanJ. Keating et al. Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci. The American Journal of Human Genetics, 2014; DOI: 10.1016/j.ajhg.2013.12.016

Cite This Page:

Queen Mary, University of London. "Eleven new genes affecting blood pressure discovered." ScienceDaily. ScienceDaily, 20 February 2014. <www.sciencedaily.com/releases/2014/02/140220141802.htm>.
Queen Mary, University of London. (2014, February 20). Eleven new genes affecting blood pressure discovered. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/02/140220141802.htm
Queen Mary, University of London. "Eleven new genes affecting blood pressure discovered." ScienceDaily. www.sciencedaily.com/releases/2014/02/140220141802.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins