Featured Research

from universities, journals, and other organizations

Antibiotic-resistant bacteria among children in U.S. on the rise

Date:
March 20, 2014
Source:
Rush University Medical Center
Summary:
Infections caused by a specific type of antibiotic-resistant bacteria are on the rise in U.S. children, according to new study. While still rare, the bacteria are increasingly found in children of all ages, especially those 1-5 years old, raising concerns about dwindling treatment options. "The overwhelming majority of current research for new pharmaceuticals against antibiotic-resistant organisms are in adults. More research is needed to define risk factors for these infections in children, their prevalence in different settings, and their molecular epidemiology," the researchers note.

Infections caused by a specific type of antibiotic-resistant bacteria are on the rise in U.S. children, according to new study published in the Journal of the Pediatric Infectious Diseases Society. While still rare, the bacteria are increasingly found in children of all ages, especially those 1-5 years old, raising concerns about dwindling treatment options.

"Some infections in children that have typically been treated with oral antibiotics in the past may now require hospitalization, treatment with intravenous drugs, or both, as there may not be an oral treatment option available," said Dr. Latania K. Logan, lead author of the study and an assistant professor of pediatrics and pediatric infectious disease specialist at Rush University Medical Center.

The team of researchers led by Logan analyzed resistance patterns in approximately 370,000 bacterial cultures from pediatric patients collected nationwide between 1999 and 2011.

They found that the prevalence is increasing in a resistant type of bacteria, which produces a key enzyme, extended-spectrum beta-lactamase (ESBL), that thwarts many strong antibiotics, making them ineffective.

Another indicator of ESBL prevalence, susceptibility to third-generation cephalosporins -- an important class of antibiotics used to treat many infections -- was also measured.

The prevalence of ESBL-producing bacteria increased from 0.28 percent to 0.92 percent from 1999 to 2011; resistance to third-generation cephalosporins increased from 1.4 percent to 3.0 percent. ESBLs were found in children across the country of all ages, but slightly more than half of the bacteria with this resistance were from those 1-5 years old. Nearly three-quarters (74.4 percent) of these bacteria were resistant to multiple classes of antibiotics.

While the overall rate of these infections in children is still low, ESBL-producing bacteria can spread rapidly and have been linked to longer hospital stays, higher health care costs, and increased mortality, the study authors noted. In a 2013 report, the Centers for Disease Control and Prevention called ESBLs a "serious concern" and a significant threat to public health.

"These antibiotic-resistant bacteria have traditionally been found in health care settings but are increasingly being found in the community, in people who have not had a significant history of health care exposure," Logan said. "In our study, though previous medical histories of the subjects were unknown, 51.3 percent of the children with these infections presented in the outpatient or ambulatory setting."

"Physicians should obtain cultures for suspected bacterial infections to help determine which antibiotics are best," said Logan.

Additional drug development, keeping younger patients in mind, is also needed. "The overwhelming majority of current research for new pharmaceuticals against antibiotic-resistant organisms are in adults," said Logan.

"More research is needed to define risk factors for these infections in children, their prevalence in different settings, and their molecular epidemiology," Logan said. A companion study by several of the same researchers is now available online in the Journal of the Pediatric Infectious Diseases Society, which suggests that children with neurologic conditions are at higher risk for infections caused by ESBL-producing bacteria.


Story Source:

The above story is based on materials provided by Rush University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. K. Logan, N. P. Braykov, R. A. Weinstein, R. Laxminarayan. Extended-Spectrum -Lactamase-Producing and Third-Generation Cephalosporin-Resistant Enterobacteriaceae in Children: Trends in the United States, 1999-2011. Journal of the Pediatric Infectious Diseases Society, 2014; DOI: 10.1093/jpids/piu010

Cite This Page:

Rush University Medical Center. "Antibiotic-resistant bacteria among children in U.S. on the rise." ScienceDaily. ScienceDaily, 20 March 2014. <www.sciencedaily.com/releases/2014/03/140320100522.htm>.
Rush University Medical Center. (2014, March 20). Antibiotic-resistant bacteria among children in U.S. on the rise. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2014/03/140320100522.htm
Rush University Medical Center. "Antibiotic-resistant bacteria among children in U.S. on the rise." ScienceDaily. www.sciencedaily.com/releases/2014/03/140320100522.htm (accessed August 1, 2014).

Share This




More Plants & Animals News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com
Visitors Feel Part of the Pack at Wolf Preserve

Visitors Feel Part of the Pack at Wolf Preserve

AP (July 31, 2014) Seacrest Wolf Preserve on the northern Florida panhandle allows more than 10,000 visitors each year to get up close and personal with Arctic and British Columbian Wolves. (July 31) Video provided by AP
Powered by NewsLook.com
Florida Panther Rebound Upsets Ranchers

Florida Panther Rebound Upsets Ranchers

AP (July 31, 2014) With Florida's panther population rebounding, some ranchers complain the protected predators are once again killing their calves. (July 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins