Featured Research

from universities, journals, and other organizations

Childhood abuse may impair weight-regulating hormones

Date:
March 20, 2014
Source:
Endocrine Society
Summary:
Childhood abuse or neglect can lead to long-term hormone impairment that raises the risk of developing obesity, diabetes or other metabolic disorders in adulthood, according to a new study. The study examined levels of the weight-regulating hormones leptin, adiponectin and irisin in the blood of adults who endured physical, emotional or sexual abuse or neglect as children. The study found dysregulation of certain hormones in people who had been abused or neglected as children.

Childhood abuse or neglect can lead to long-term hormone impairment that raises the risk of developing obesity, diabetes or other metabolic disorders in adulthood, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

The study examined levels of the weight-regulating hormones leptin, adiponectin and irisin in the blood of adults who endured physical, emotional or sexual abuse or neglect as children. Leptin is involved in regulating appetite and is linked to body-mass index (BMI) and fat mass. The hormone irisin is involved in energy metabolism. Adiponectin reduces inflammation in the body, and obese people tend to have lower levels of the hormone. The study found dysregulation of these hormones in people who had been abused or neglected as children.

"This study helps illuminate why people who have dealt with childhood adversity face a higher risk of developing excess belly fat and related health conditions," said one of the study's authors, Christos S. Mantzoros, MD, DSc, PhD, of Beth Israel Deaconess Medical Center and the VA Boston Healthcare System, both affiliated with Harvard Medical School in Boston, MA. "The data suggest that childhood adversity places stress on the endocrine system, leading to impairment of important hormones that can contribute to abdominal obesity well into adulthood."

The cross-sectional study examined hormone levels in the blood of 95 adults ages 35 to 65. Using questionnaires and interviews, each participant was assigned a score based on the severity of the abuse or neglect experienced during childhood. Researchers divided the participants into three groups and compared hormone levels in people with the highest adversity scores to the other two-thirds of the participants.

Participants with the highest adversity scores tended to have higher levels of leptin, irisin and the inflammatory marker C-reactive protein in their blood. All of these markers are linked to obesity. In addition, the group of people who suffered the most adversity tended to have lower levels of adiponectin, another risk factor for obesity. Even after researchers adjusted for differences in diet, exercise and demographic variables among the participants, high levels of leptin and irisin continued to be associated with childhood adversity.

"What we are seeing is a direct correlation between childhood adversity and hormone impairment, over and above the impact abuse or neglect may have on lifestyle factors such as diet and education," Mantzoros said. "Understanding these mechanisms could help health care providers develop new and better interventions to address this population's elevated risk of abdominal obesity and cardiometabolic risk later in life."


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kyoung Eun Joung, Kyung-Hee Park, Lesya Zaichenko, Ayse Sahin-Efe, Bindiya Thakkar, Mary Brinkoetter, Nicole Usher, Dorothy Warner, Cynthia R. Davis, Judith A. Crowell, Christos S. Mantzoros. Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults. The Journal of Clinical Endocrinology & Metabolism, 2014; jc.2013-3669 DOI: 10.1210/jc.2013-3669

Cite This Page:

Endocrine Society. "Childhood abuse may impair weight-regulating hormones." ScienceDaily. ScienceDaily, 20 March 2014. <www.sciencedaily.com/releases/2014/03/140320134722.htm>.
Endocrine Society. (2014, March 20). Childhood abuse may impair weight-regulating hormones. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2014/03/140320134722.htm
Endocrine Society. "Childhood abuse may impair weight-regulating hormones." ScienceDaily. www.sciencedaily.com/releases/2014/03/140320134722.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins