Featured Research

from universities, journals, and other organizations

Childhood abuse may impair weight-regulating hormones

Date:
March 20, 2014
Source:
Endocrine Society
Summary:
Childhood abuse or neglect can lead to long-term hormone impairment that raises the risk of developing obesity, diabetes or other metabolic disorders in adulthood, according to a new study. The study examined levels of the weight-regulating hormones leptin, adiponectin and irisin in the blood of adults who endured physical, emotional or sexual abuse or neglect as children. The study found dysregulation of certain hormones in people who had been abused or neglected as children.

Childhood abuse or neglect can lead to long-term hormone impairment that raises the risk of developing obesity, diabetes or other metabolic disorders in adulthood, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

The study examined levels of the weight-regulating hormones leptin, adiponectin and irisin in the blood of adults who endured physical, emotional or sexual abuse or neglect as children. Leptin is involved in regulating appetite and is linked to body-mass index (BMI) and fat mass. The hormone irisin is involved in energy metabolism. Adiponectin reduces inflammation in the body, and obese people tend to have lower levels of the hormone. The study found dysregulation of these hormones in people who had been abused or neglected as children.

"This study helps illuminate why people who have dealt with childhood adversity face a higher risk of developing excess belly fat and related health conditions," said one of the study's authors, Christos S. Mantzoros, MD, DSc, PhD, of Beth Israel Deaconess Medical Center and the VA Boston Healthcare System, both affiliated with Harvard Medical School in Boston, MA. "The data suggest that childhood adversity places stress on the endocrine system, leading to impairment of important hormones that can contribute to abdominal obesity well into adulthood."

The cross-sectional study examined hormone levels in the blood of 95 adults ages 35 to 65. Using questionnaires and interviews, each participant was assigned a score based on the severity of the abuse or neglect experienced during childhood. Researchers divided the participants into three groups and compared hormone levels in people with the highest adversity scores to the other two-thirds of the participants.

Participants with the highest adversity scores tended to have higher levels of leptin, irisin and the inflammatory marker C-reactive protein in their blood. All of these markers are linked to obesity. In addition, the group of people who suffered the most adversity tended to have lower levels of adiponectin, another risk factor for obesity. Even after researchers adjusted for differences in diet, exercise and demographic variables among the participants, high levels of leptin and irisin continued to be associated with childhood adversity.

"What we are seeing is a direct correlation between childhood adversity and hormone impairment, over and above the impact abuse or neglect may have on lifestyle factors such as diet and education," Mantzoros said. "Understanding these mechanisms could help health care providers develop new and better interventions to address this population's elevated risk of abdominal obesity and cardiometabolic risk later in life."


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kyoung Eun Joung, Kyung-Hee Park, Lesya Zaichenko, Ayse Sahin-Efe, Bindiya Thakkar, Mary Brinkoetter, Nicole Usher, Dorothy Warner, Cynthia R. Davis, Judith A. Crowell, Christos S. Mantzoros. Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults. The Journal of Clinical Endocrinology & Metabolism, 2014; jc.2013-3669 DOI: 10.1210/jc.2013-3669

Cite This Page:

Endocrine Society. "Childhood abuse may impair weight-regulating hormones." ScienceDaily. ScienceDaily, 20 March 2014. <www.sciencedaily.com/releases/2014/03/140320134722.htm>.
Endocrine Society. (2014, March 20). Childhood abuse may impair weight-regulating hormones. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/03/140320134722.htm
Endocrine Society. "Childhood abuse may impair weight-regulating hormones." ScienceDaily. www.sciencedaily.com/releases/2014/03/140320134722.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins