Featured Research

from universities, journals, and other organizations

Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill

Date:
March 27, 2014
Source:
Genetics Society of America
Summary:
Cells usually self-destruct when irreparable glitches occur in their DNA. Programmed cell death, or apoptosis, helps insure that cells with damaged DNA do not grow and replicate to produce more mutated cells. Apoptosis thereby helps protect and insure the survival of the organism. Scientists now report that a dying Drosophila melanogaster larvae cell alerts neighboring cells that they are in danger of suffering a similar fate.

Illustration of cells (stock image). The dying cell's signaling its neighbors to protect themselves from apoptosis challenges the long held view that cells in the vicinity of dying, irradiated cells become more prone to death.
Credit: zinco79 / Fotolia

Cells usually self-destruct when irreparable glitches occur in their DNA. Programmed cell death, or apoptosis, helps insure that cells with damaged DNA do not grow and replicate to produce more mutated cells. Apoptosis thereby helps protect and insure the survival of the organism.

Related Articles


At the GSA Drosophila Research Conference, TinTin Su, Ph.D., will report that a dying Drosophila melanogaster larvae cell alerts neighboring cells that they are in danger of suffering a similar fate.

Dr. Su and her collaborators at University of Colorado, Boulder used ionizing radiation (IR) to induce DNA damage and apoptosis in cells of the wing imaginal disc, the immature form of the fly's wings. The neighboring cells responded by activating bantam, a microRNA. As a result, the neighboring cells became more difficult to kill by IR.

The scientists determined that the key to this process was the receptor tyrosine kinase Tie. The dying cell's signal turned on Tie, thereby activating the short microRNA molecule bantam.

Previously the only known role for Tie in fruit flies was in long-range signaling in border cell migration. Although Tie is not required for normal larval development, it becomes necessary for survival after radiation exposure, Dr. Su noted.

The dying cell's signaling its neighbors to protect themselves from apoptosis challenges the long held view that cells in the vicinity of dying, irradiated cells become more prone to death. The results of the experiments conducted by Dr. Su and her collaborators also complement previous studies that showed that a larval disc cell's death leads to proliferation of cells in the disc.

If this protective mechanism also operates in mammals, it may affect the results of the sequential use of cytotoxic agents and radiation in cancer therapy, she pointed out.

Link to presentation abstract: http://abstracts.genetics-gsa.org/cgi-bin/dros14s/showdetail.pl?absno=14531034


Story Source:

The above story is based on materials provided by Genetics Society of America. Note: Materials may be edited for content and length.


Cite This Page:

Genetics Society of America. "Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill." ScienceDaily. ScienceDaily, 27 March 2014. <www.sciencedaily.com/releases/2014/03/140327111231.htm>.
Genetics Society of America. (2014, March 27). Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill. ScienceDaily. Retrieved April 25, 2015 from www.sciencedaily.com/releases/2014/03/140327111231.htm
Genetics Society of America. "Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill." ScienceDaily. www.sciencedaily.com/releases/2014/03/140327111231.htm (accessed April 25, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, April 25, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dispute Flares Over Controversial Thai Temple Tigers

Dispute Flares Over Controversial Thai Temple Tigers

AFP (Apr. 24, 2015) Thai wildlife officials begin a headcount of nearly 150 tigers kept by monks at a temple which has become the centre of a dispute over the welfare of the animals. Video provided by AFP
Powered by NewsLook.com
College Kegger: University Gets in on Craft Brew

College Kegger: University Gets in on Craft Brew

AP (Apr. 24, 2015) Theres never been a shortage of beer on college campuses. But students at Cal Poly-Pomona are learning how to brew, serving their product to classmates, and hoping to land jobs in craft breweries when they graduate. (April 24) Video provided by AP
Powered by NewsLook.com
Cambodian Butterflies Help Villagers Make a Living

Cambodian Butterflies Help Villagers Make a Living

AFP (Apr. 24, 2015) Cambodia&apos;s Banteay Srey Butterfly Centre is the largest of its kind in Southeast Asia. As well as educating tourists about the creatures, it also offers a source of income to nearby villagers, who are paid to breed local species. Duration: 02:04 Video provided by AFP
Powered by NewsLook.com
3D Food Printing: The Meal of the Future?

3D Food Printing: The Meal of the Future?

AP (Apr. 23, 2015) Developers of 3D food printing hope the culinary technology will revolutionize the way we cook and eat. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins