Featured Research

from universities, journals, and other organizations

Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill

Date:
March 27, 2014
Source:
Genetics Society of America
Summary:
Cells usually self-destruct when irreparable glitches occur in their DNA. Programmed cell death, or apoptosis, helps insure that cells with damaged DNA do not grow and replicate to produce more mutated cells. Apoptosis thereby helps protect and insure the survival of the organism. Scientists now report that a dying Drosophila melanogaster larvae cell alerts neighboring cells that they are in danger of suffering a similar fate.

Illustration of cells (stock image). The dying cell's signaling its neighbors to protect themselves from apoptosis challenges the long held view that cells in the vicinity of dying, irradiated cells become more prone to death.
Credit: zinco79 / Fotolia

Cells usually self-destruct when irreparable glitches occur in their DNA. Programmed cell death, or apoptosis, helps insure that cells with damaged DNA do not grow and replicate to produce more mutated cells. Apoptosis thereby helps protect and insure the survival of the organism.

At the GSA Drosophila Research Conference, TinTin Su, Ph.D., will report that a dying Drosophila melanogaster larvae cell alerts neighboring cells that they are in danger of suffering a similar fate.

Dr. Su and her collaborators at University of Colorado, Boulder used ionizing radiation (IR) to induce DNA damage and apoptosis in cells of the wing imaginal disc, the immature form of the fly's wings. The neighboring cells responded by activating bantam, a microRNA. As a result, the neighboring cells became more difficult to kill by IR.

The scientists determined that the key to this process was the receptor tyrosine kinase Tie. The dying cell's signal turned on Tie, thereby activating the short microRNA molecule bantam.

Previously the only known role for Tie in fruit flies was in long-range signaling in border cell migration. Although Tie is not required for normal larval development, it becomes necessary for survival after radiation exposure, Dr. Su noted.

The dying cell's signaling its neighbors to protect themselves from apoptosis challenges the long held view that cells in the vicinity of dying, irradiated cells become more prone to death. The results of the experiments conducted by Dr. Su and her collaborators also complement previous studies that showed that a larval disc cell's death leads to proliferation of cells in the disc.

If this protective mechanism also operates in mammals, it may affect the results of the sequential use of cytotoxic agents and radiation in cancer therapy, she pointed out.

Link to presentation abstract: http://abstracts.genetics-gsa.org/cgi-bin/dros14s/showdetail.pl?absno=14531034


Story Source:

The above story is based on materials provided by Genetics Society of America. Note: Materials may be edited for content and length.


Cite This Page:

Genetics Society of America. "Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill." ScienceDaily. ScienceDaily, 27 March 2014. <www.sciencedaily.com/releases/2014/03/140327111231.htm>.
Genetics Society of America. (2014, March 27). Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2014/03/140327111231.htm
Genetics Society of America. "Dying cells in fruit fly alert neighboring cells to protect themselves: As a result, neighbors become harder to kill." ScienceDaily. www.sciencedaily.com/releases/2014/03/140327111231.htm (accessed July 29, 2014).

Share This




More Plants & Animals News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
Asteroid's Timing Was 'Colossal Bad Luck' For The Dinosaurs

Asteroid's Timing Was 'Colossal Bad Luck' For The Dinosaurs

Newsy (July 28, 2014) The asteroid that killed the dinosaurs struck at the worst time for them. A new study says that if it hit earlier or later, they might've survived. Video provided by Newsy
Powered by NewsLook.com
Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins