Featured Research

from universities, journals, and other organizations

Enhancing immune response through next generation polymeric vaccine adjuvants

Date:
April 3, 2014
Source:
World Scientific
Summary:
Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to pathogens. Adjuvants are especially necessary to boost the immune response for subunit vaccines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

The easily modifiable properties of polymers and their potential for functionalization, shown in blue and red respectively, make them attractive candidates for replacing conventional adjuvants.
Credit: Image courtesy of World Scientific

The great success of vaccines over the past two centuries as a preventive medicine has led to a significant reduction in morbidity and death caused by controllable infectious diseases. The effectiveness of vaccines is dependent on their ability to induce a protective immune response in recipients. Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to pathogens.

Adjuvants are especially necessary to boost the immune response for subunit vaccines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

This review article appearing in Technology and submitted by researchers from Iowa State University investigates the potential of polymeric adjuvants, both natural and synthetic. In addition to a comprehensive study of their use in vaccines, this article summarizes the benefits and challenges associated with the use of these polymer systems as adjuvants.


Story Source:

The above story is based on materials provided by World Scientific. Note: Materials may be edited for content and length.


Journal Reference:

  1. Justin R. Adams, Surya K. Mallapragada. Enhancing the immune response through next generation polymeric vaccine adjuvants. TECHNOLOGY, 2014; 02 (01): 1 DOI: 10.1142/S2339547814300017

Cite This Page:

World Scientific. "Enhancing immune response through next generation polymeric vaccine adjuvants." ScienceDaily. ScienceDaily, 3 April 2014. <www.sciencedaily.com/releases/2014/04/140403095505.htm>.
World Scientific. (2014, April 3). Enhancing immune response through next generation polymeric vaccine adjuvants. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/04/140403095505.htm
World Scientific. "Enhancing immune response through next generation polymeric vaccine adjuvants." ScienceDaily. www.sciencedaily.com/releases/2014/04/140403095505.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins