Featured Research

from universities, journals, and other organizations

Enhancing immune response through next generation polymeric vaccine adjuvants

Date:
April 3, 2014
Source:
World Scientific
Summary:
Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to pathogens. Adjuvants are especially necessary to boost the immune response for subunit vaccines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

The easily modifiable properties of polymers and their potential for functionalization, shown in blue and red respectively, make them attractive candidates for replacing conventional adjuvants.
Credit: Image courtesy of World Scientific

The great success of vaccines over the past two centuries as a preventive medicine has led to a significant reduction in morbidity and death caused by controllable infectious diseases. The effectiveness of vaccines is dependent on their ability to induce a protective immune response in recipients. Adjuvants, such as aluminum salts, have been integrated into vaccines for more than 70 years to augment the body's immune response to pathogens.

Adjuvants are especially necessary to boost the immune response for subunit vaccines. However, conventional adjuvants are limited by their toxicity and limited cellular immune responses. Polymeric adjuvants in the form of nanoparticles, matrices or micelles have the ability to prompt strong adaptive immune responses without sacrificing biocompatibility.

This review article appearing in Technology and submitted by researchers from Iowa State University investigates the potential of polymeric adjuvants, both natural and synthetic. In addition to a comprehensive study of their use in vaccines, this article summarizes the benefits and challenges associated with the use of these polymer systems as adjuvants.


Story Source:

The above story is based on materials provided by World Scientific. Note: Materials may be edited for content and length.


Journal Reference:

  1. Justin R. Adams, Surya K. Mallapragada. Enhancing the immune response through next generation polymeric vaccine adjuvants. TECHNOLOGY, 2014; 02 (01): 1 DOI: 10.1142/S2339547814300017

Cite This Page:

World Scientific. "Enhancing immune response through next generation polymeric vaccine adjuvants." ScienceDaily. ScienceDaily, 3 April 2014. <www.sciencedaily.com/releases/2014/04/140403095505.htm>.
World Scientific. (2014, April 3). Enhancing immune response through next generation polymeric vaccine adjuvants. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2014/04/140403095505.htm
World Scientific. "Enhancing immune response through next generation polymeric vaccine adjuvants." ScienceDaily. www.sciencedaily.com/releases/2014/04/140403095505.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins