Featured Research

from universities, journals, and other organizations

Disruption of VISTA plays an important role in regulating immune response

Date:
April 7, 2014
Source:
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center
Summary:
The body’s immune system response was enhanced in a study when researchers disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors.

Researchers at the Geisel School of Medicine at Dartmouth have found that the body's immune system response was enhanced when they disrupted VISTA, a protein that prevents the immune system from overreacting. Understanding how checkpoint regulators like VISTA function is important to cancer researchers, who hope to use the immune system to attack tumors.

The study, "VISTA deficiency synergizes with a nonredundant immune checkpoint pathway and leads to enhanced immune activation," will be presented on April 7, 2014 at the American Association for Cancer Research Annual Meeting in San Diego, CA.

"Because there are multiple immune suppressive pathways, disrupting a single pathway like VISTA might not have led us to obvious alterations in the immune response," said Li Wang, PhD, assistant professor of Microbiology and Immunology at Geisel.

"Our data showed clear chronic inflammation due to VISTA deficiency, which leads us to conclude that VISTA likely plays an important role in regulating immunity."

Wang and her colleagues hope to build on these findings to define the molecular pathway involved in VISTA-mediated immune regulation.


Story Source:

The above story is based on materials provided by Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. "Disruption of VISTA plays an important role in regulating immune response." ScienceDaily. ScienceDaily, 7 April 2014. <www.sciencedaily.com/releases/2014/04/140407113109.htm>.
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. (2014, April 7). Disruption of VISTA plays an important role in regulating immune response. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2014/04/140407113109.htm
Norris Cotton Cancer CenterDartmouth-Hitchcock Medical Center. "Disruption of VISTA plays an important role in regulating immune response." ScienceDaily. www.sciencedaily.com/releases/2014/04/140407113109.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com
How A 'Rule Of Thumb' Could Slow Down Drinking

How A 'Rule Of Thumb' Could Slow Down Drinking

Newsy (Aug. 28, 2014) A study suggests people who follow a "rule of thumb" when pouring wine dispense less than those who don't have a particular amount in mind. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins