Featured Research

from universities, journals, and other organizations

Common diabetes treatment could extend hypoglycemia

Date:
April 8, 2014
Source:
University of Adelaide
Summary:
A common treatment for people with type 2 diabetes could cause longer-than-normal periods of the low blood sugar reaction hypoglycemia, which may result in increased health risks to people with diabetes. The treatment is the use of the peptide GLP-1 (glucagon-like peptide 1) in combination with insulin, which is now used throughout the world as a standard therapy for patients with type 2 diabetes.

Researchers at the University of Adelaide have discovered that a common treatment for people with type 2 diabetes could cause longer-than-normal periods of the low blood sugar reaction hypoglycemia, which may result in increased health risks to people with diabetes.

The treatment is the use of the peptide GLP-1 (glucagon-like peptide 1) in combination with insulin, which is now used throughout the world as a standard therapy for patients with type 2 diabetes.

A team of researchers at the University of Adelaide's School of Medicine has investigated the impact of this combination therapy on how quickly the stomach empties after eating food.

The results, now published online in the journal Diabetes Care, show that the combination of GLP-1 and insulin slows down the rate of food being emptied from the stomach.

"Low blood sugar levels usually cause the stomach to empty rapidly, however in the group studied on GLP-1 therapy it emptied no more quickly than at normal blood glucose levels," says lead author and University of Adelaide PhD student Dr Mark Plummer.

"This is a concern because it means that a significant amount of food, and therefore glucose being consumed by a diabetic patient to prevent or treat hypoglycemia, is being retained in the stomach. This would have the effect of extending hypoglycemia and potentially putting the patient at risk."

Dr Plummer says the sample group of 10 people was relatively small, "but statistically the results were significant."

"A diabetic patient really doesn't want their blood sugars to go too low because the brain requires glucose for normal functioning and you run the risk of loss of consciousness, seizures and even death in extreme cases," he says.

"There were no life-threatening effects on the patients we studied, but their symptoms included sweating, palpitations and visual disturbance."

Dr Plummer says the study highlights the potential safety implications for the combination of GLP-1 with other therapies known to induce hypoglycemia. "Further research is needed in this area. We believe there should be ongoing evaluation of this combination therapy for patients with type 2 diabetes, to better understand the risks associated with it."


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. P. Plummer, K. L. Jones, C. E. Annink, C. E. Cousins, J. J. Meier, M. J. Chapman, M. Horowitz, A. M. Deane. Glucagon-Like Peptide 1 Attenuates the Acceleration of Gastric Emptying Induced by Hypoglycemia in Healthy Subjects. Diabetes Care, 2014; DOI: 10.2337/dc13-1813

Cite This Page:

University of Adelaide. "Common diabetes treatment could extend hypoglycemia." ScienceDaily. ScienceDaily, 8 April 2014. <www.sciencedaily.com/releases/2014/04/140408111224.htm>.
University of Adelaide. (2014, April 8). Common diabetes treatment could extend hypoglycemia. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/04/140408111224.htm
University of Adelaide. "Common diabetes treatment could extend hypoglycemia." ScienceDaily. www.sciencedaily.com/releases/2014/04/140408111224.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins