Featured Research

from universities, journals, and other organizations

How our immune system kills abnormal blood cells

Date:
April 8, 2014
Source:
Institut de recherches cliniques de Montreal
Summary:
A team of researchers explains how our immune system kills abnormal blood cells. Their discovery could eventually lead to new treatment avenues for leukemia, lymphoma and certain types of infectious viral diseases. "Our team is studying how natural killer cells can eliminate abnormal hematopoietic (blood) cells," explains the lead researcher. "Natural killer cells are crucial to the immune system and play a critical role in protecting us against viruses and cancer cells."

A team of researchers at the IRCM, led by Andrι Veillette, MD, explains how our immune system kills abnormal blood cells. Their discovery, recently published in the Journal of Experimental Medicine, could eventually lead to new treatment avenues for leukemia, lymphoma and certain types of infectious viral diseases.

Related Articles


"Our team is studying how natural killer cells can eliminate abnormal hematopoietic (blood) cells," explains Dr. Veillette, Director of the Molecular Oncology research unit at the IRCM. "NK (natural killer) cells are crucial to the immune system and play a critical role in protecting us against viruses and cancer cells."

In a previous study, the IRCM researchers found the SAP molecule to be an essential component of NK cells' ability to kill abnormal blood cells, which can be found in blood cancers such as leukemia and lymphoma, as well as in certain infectious viral diseases like infectious mononucleosis.

"In addition to SAP, a protein called EAT-2 can also be found in NK cells," adds Dr. Veillette. "We knew that EAT-2 cooperates with SAP, and, with this research project, we wanted to better understand why they are both required for the proper functioning of NK cells."

Using a variety of genetic, biochemical and imaging approaches, the researchers successfully defined the molecular and cellular mechanisms by which EAT-2 controls the activation of NK cells.

"We identified the molecular chain of events that occur, and showed that EAT-2 and SAP perform different functions using distinct mechanisms," says Dr. Veillette. "These findings explain the cooperative and essential function of these two molecules in activating NK cells, thereby allowing them to kill abnormal blood cells."

"EAT-2 and SAP are molecules found inside NK cells, and they are linked to receptors of the SLAM family on the cell surface," concludes Dr. Veillette. "Because they can make better drug targets, our future work will focus on these receptors, which could eventually lead to identifying new potential treatment avenues for blood cancers such as leukemia and lymphoma."

According to the Leukemia & Lymphoma Society of Canada, one person in Canada is diagnosed with a blood cancer approximately every 28 minutes. In 2013, leukemia, lymphoma, myeloma and myelodysplastic syndromes caused an estimated 6,850 deaths in the country. Leukemia and lymphoma also account for almost half of all childhood cancers (age 0-14 years).


Story Source:

The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. L.-A. Perez-Quintero, R. Roncagalli, H. Guo, S. Latour, D. Davidson, A. Veillette. EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C , Ca , and Erk, leading to granule polarization. Journal of Experimental Medicine, 2014; 211 (4): 727 DOI: 10.1084/jem.20132038

Cite This Page:

Institut de recherches cliniques de Montreal. "How our immune system kills abnormal blood cells." ScienceDaily. ScienceDaily, 8 April 2014. <www.sciencedaily.com/releases/2014/04/140408111918.htm>.
Institut de recherches cliniques de Montreal. (2014, April 8). How our immune system kills abnormal blood cells. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2014/04/140408111918.htm
Institut de recherches cliniques de Montreal. "How our immune system kills abnormal blood cells." ScienceDaily. www.sciencedaily.com/releases/2014/04/140408111918.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cherries, Snap Peas and More Tasty Spring Produce

Cherries, Snap Peas and More Tasty Spring Produce

Buzz60 (Feb. 27, 2015) — From sweet cherries to sugar snap peas, spring is the peak season for some of the tastiest and healthiest produce. Krystin Goodwin (@Krystingoodwin) has the best seasonal fruits and veggies to spring in to good health! Video provided by Buzz60
Powered by NewsLook.com
New FDA-Approved Diabetes Medicine Might Save Drugmaker

New FDA-Approved Diabetes Medicine Might Save Drugmaker

Newsy (Feb. 26, 2015) — The U.S. Food and Drug Administration approved new diabetes drug Toujeo on Wednesday, a move that might save French drugmaker Sanofi&apos;s profits. Video provided by Newsy
Powered by NewsLook.com
The Best Foods to Battle Stress

The Best Foods to Battle Stress

Buzz60 (Feb. 26, 2015) — If you&apos;re dealing with anxiety, there are a few foods that can help. Krystin Goodwin (@krystingoodwin) has the best foods to tame stress. Video provided by Buzz60
Powered by NewsLook.com
The 5 Best Tips to Look Younger Now

The 5 Best Tips to Look Younger Now

Buzz60 (Feb. 26, 2015) — Life happens, and we all get older, but forget the pricey anti-aging products and plastic surgery. You can tweak your habits to turn back the hands of time. Krystin Goodwin (@krystingoodwin) has a few simple tips to help you look and feel younger. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins