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Positive outcomes for hepatitis C transplant patients

Date:
April 11, 2014
Source:
European Association for the Study of the Liver
Summary:
There is new hope for the notoriously difficult-to-treat population of liver transplant patients with recurring hepatitis C, researchers have announced. Hepatitis C infection is a common cause of liver transplantation, with virus-related diseases comprising 40% of primary indications for liver transplantation in Europe among patients with cirrhosis. More than 5,500 liver transplantations are currently performed in Europe per year.

New research announced at the International Liver CongressTM 2014 today provides new hope for the notoriously difficult-to-treat population of liver transplant patients with recurring hepatitis C (HCV).

As part of a compassionate use program, 104 post-liver transplant patients with recurring HCV who had exhausted all treatment options and had poor clinical prognoses, received sofosbuvir (SOF) and ribavirin (RBV) with pegylated interferon (PEG) included at the physicians' discretion for up to 48 weeks. Among patients whose clinical outcomes have been reported, 62% achieved SVR12. Additionally, 62% of patients had improvements in clinical conditions associated with hepatic decompensation (e.g., ascites and encephalopathy) and/or improvement in liver function tests. SOF+RBV±PEG was well-tolerated and led to high rates of virologic suppression.

EASL's European Policy Councillor Professor Patrizia Burra of the Multivisceral Transplant Unit, Padova University Hospital, Padua, Italy said: "There are currently no effective treatment options for this patient group. However, this new trial involving the nucleotide polymerase inhibitor sofosbuvir (SOF) has demonstrated promising results, providing further evidence of its clinical potential."

"For patients with advanced hepatitis C liver disease, liver transplants offer a second chance," continued Professor Burra, "and for those who continue to suffer post-surgery, it's important for us to keep following up all avenues possible to improve their quality of life."

Other research revealed at the International Liver CongressTM 2014 showed that most patients with mild hepatitis C recurrence diagnosed one year after liver transplant have excellent long-term outcomes.

In the second study, 172 patients who were diagnosed with mild hepatitis C recurrence one year after undergoing liver transplant surgery between 1999 and 2012 were followed for six and a half years with all relevant transplant-related, donor and recipient variables recorded. The cumulative probability of HCV-related graft loss five and 10 years after liver transplant were 3% and 10%, respectively.

However one third of these patients are still at risk of going on to develop cirrhosis, further demonstrating the need for antiviral therapy pre or post-transplant.

Hepatitis C infection is a common cause of liver transplantation, with virus-related diseases comprising 40% of primary indications for liver transplantation in Europe among patients with cirrhosis.

More than 5,500 liver transplantations are currently performed in Europe per year.


Story Source:

The above story is based on materials provided by European Association for the Study of the Liver. Note: Materials may be edited for content and length.


Cite This Page:

European Association for the Study of the Liver. "Positive outcomes for hepatitis C transplant patients." ScienceDaily. ScienceDaily, 11 April 2014. <www.sciencedaily.com/releases/2014/04/140411091834.htm>.
European Association for the Study of the Liver. (2014, April 11). Positive outcomes for hepatitis C transplant patients. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/04/140411091834.htm
European Association for the Study of the Liver. "Positive outcomes for hepatitis C transplant patients." ScienceDaily. www.sciencedaily.com/releases/2014/04/140411091834.htm (accessed July 31, 2014).

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