Featured Research

from universities, journals, and other organizations

Anti-seizure drug may reduce alcohol consumption, study shows

Date:
April 17, 2014
Source:
Boston University Medical Center
Summary:
The anti-seizure drug ezogabine, reduced alcohol consumption in an experimental model, researchers report. The findings may lead to more effective treatments for alcoholism. Excessive consumption of alcohol is one of the leading causes of illness and death in the U.S. and has significant negative economic impact by limiting the productivity of workers and necessitating huge health care expenditures.

Researchers from Boston University School of Medicine (BUSM) have discovered that the anti-seizure drug ezogabine, reduced alcohol consumption in an experimental model. The findings, reported in the American Journal of Drug and Alcohol Abuse, may lead to more effective treatments for alcoholism.

Excessive consumption of alcohol is one of the leading causes of illness and death in the U.S. and has significant negative economic impact by limiting the productivity of workers and necessitating huge health care expenditures.

According to the researchers, this study provides the first evidence that alcoholism can be treated by this newly discovered mechanism that helps to regulate brain activity known as Kv7 channel modulation. "This finding is of importance because ezogabine acts by opening a particular type of potassium channel in the brain, called the Kv7 channel, which regulates activity in areas of the brain that are believed to regulate the rewarding effects of alcohol," explained lead author Clifford Knapp, PhD, associate professor of psychiatry at BUSM. "This research indicates that drugs that open Kv7 channels might be of value in the treatment of alcoholism," he added.

Previous studies conducted by this research group helped to establish the value of anti-seizure drugs as medications to treat alcoholism. However, further research needs to be conducted to establish that the effects of this drug result primarily from its actions on Kv7 channels. "Because of the close proximity of the doses at which ezogabine reduces drinking and those at which it is reported to produce motor impairment, it is still important to continue to investigate how selective the actions of ezogabine are on the neuronal mechanisms that control alcohol consumption," said Knapp.

The researchers believe these finding will encourage the search for other drugs that act on this system to discover more effective treatments for alcoholism.


Story Source:

The above story is based on materials provided by Boston University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Clifford M. Knapp, Matthew O’Malley, Subimal Datta, Domenic A. Ciraulo. The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats. The American Journal of Drug and Alcohol Abuse, 2014; 1 DOI: 10.3109/00952990.2014.892951

Cite This Page:

Boston University Medical Center. "Anti-seizure drug may reduce alcohol consumption, study shows." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417133503.htm>.
Boston University Medical Center. (2014, April 17). Anti-seizure drug may reduce alcohol consumption, study shows. ScienceDaily. Retrieved September 14, 2014 from www.sciencedaily.com/releases/2014/04/140417133503.htm
Boston University Medical Center. "Anti-seizure drug may reduce alcohol consumption, study shows." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417133503.htm (accessed September 14, 2014).

Share This



More Mind & Brain News

Sunday, September 14, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
'Magic Mushrooms' Could Help Smokers Quit

'Magic Mushrooms' Could Help Smokers Quit

Newsy (Sep. 11, 2014) In a small study, researchers found that the majority of long-time smokers quit after taking psilocybin pills and undergoing therapy sessions. Video provided by Newsy
Powered by NewsLook.com
'Fat Shaming' Might Actually Cause Weight Gain

'Fat Shaming' Might Actually Cause Weight Gain

Newsy (Sep. 11, 2014) A study for University College London suggests obese people who are discriminated against gain more weight than those who are not. Video provided by Newsy
Powered by NewsLook.com
Common Sleeping, Anxiety Pills Linked To Alzheimer's

Common Sleeping, Anxiety Pills Linked To Alzheimer's

Newsy (Sep. 10, 2014) Researchers found commonly prescribed sleeping and anxiety pills such as Xanax and Valium could lead to an increased risk for Alzheimer's disease. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins