Featured Research

from universities, journals, and other organizations

Influenza, bacterial superinfections reviewed in journal

Date:
April 17, 2014
Source:
Le Bonheur Children's Hospital
Summary:
An expert has analyzed the epidemiology and microbiology of co-infections during the 1918, 1957 and 1968 pandemics, as well as more recent 2009 novel H1N1 pandemic, and published a review on this analysis. Specifically, the co-pathogenesis reviewed is characterized by complex interactions between co-infecting pathogens and the host, leading to the disruption of physical barriers, dysregulation of immune responses and delays in a return to homeostasis.

Le Bonheur Children's Hospital Pediatrician-in-Chief Jon McCullers, MD, was recently invited to submit a review in the April issue of Nature Reviews Microbiology, one of the world's foremost scientific publications. Dr. McCullers, an infectious disease specialist, and chair of the Department of Pediatrics at the University of Tennessee Health Science Center, analyzed the epidemiology and microbiology of co-infections during the 1918, 1957 and 1968 pandemics, as well as more recent 2009 novel H1N1 pandemic.

He reviewed the co-pathogenesis of influenza viruses with bacteria in the lung. Bacterial superinfection in the lungs of those suffering from influenza is a key element that promotes severe disease and mortality.

The co-pathogenesis McCullers reviewed is characterized by complex interactions between co-infecting pathogens and the host, leading to the disruption of physical barriers, dysregulation of immune responses and delays in a return to homeostasis.

The net effect of this cascade can be the outgrowth of the pathogens, immune-mediated pathology and increased morbidity.

McCullers calls for large-scale studies involving consortia or clinical networks to unlock the next unanswered questions about co-infections and viruses in order to prevent the loss of life of a pandemic similar to the one in 1918.

"There is increasing recognition that most pneumonia is caused by co-infections rather than a single pathogen, and the most severe disease seen in influenza pandemics is mediated by co-infecting bacteria working with the virus," said McCullers. "The scientific community must help the world prepare for the next pandemic by understanding a set of key, unanswered questions that are addressed in this review."


Story Source:

The above story is based on materials provided by Le Bonheur Children's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jonathan A. McCullers. The co-pathogenesis of influenza viruses with bacteria in the lung. Nature Reviews Microbiology, 2014; 12 (4): 252 DOI: 10.1038/nrmicro3231

Cite This Page:

Le Bonheur Children's Hospital. "Influenza, bacterial superinfections reviewed in journal." ScienceDaily. ScienceDaily, 17 April 2014. <www.sciencedaily.com/releases/2014/04/140417164158.htm>.
Le Bonheur Children's Hospital. (2014, April 17). Influenza, bacterial superinfections reviewed in journal. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2014/04/140417164158.htm
Le Bonheur Children's Hospital. "Influenza, bacterial superinfections reviewed in journal." ScienceDaily. www.sciencedaily.com/releases/2014/04/140417164158.htm (accessed October 1, 2014).

Share This



More Plants & Animals News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) — Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com
Cultural Learning In Wild Chimps Observed For The First Time

Cultural Learning In Wild Chimps Observed For The First Time

Newsy (Oct. 1, 2014) — Cultural transmission — the passing of knowledge from one animal to another — has been caught on camera with chimps teaching other chimps. Video provided by Newsy
Powered by NewsLook.com
Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Earth Has Lost Half Its Vertebrate Wildlife Since 1970: WWF

Newsy (Sep. 30, 2014) — A new study published by the World Wide Fund for Nature found that more than half of the world's wildlife population has declined since 1970. Video provided by Newsy
Powered by NewsLook.com
Annual Dog Surfing Competition Draws California Crowds

Annual Dog Surfing Competition Draws California Crowds

AFP (Sep. 30, 2014) — The best canine surfers gathered for Huntington Beach's annual dog surfing competition, "Surf City, Surf Dog." Duration: 01:15 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins