Featured Research

from universities, journals, and other organizations

Male health linked to testosterone exposure in womb, study finds

Date:
April 22, 2014
Source:
University of Edinburgh
Summary:
Men's susceptibility to serious health conditions may be influenced by low exposure to testosterone in the womb, new research suggests. Understanding why some men have less of the hormone than others is important because testosterone is crucial for life-long health. Low levels of the hormone have been linked to obesity, diabetes and heart disease.

Woman hands holding ultrasound of baby in womb (stock image). A study has revealed how men's testosterone levels may be determined before they are born.
Credit: Valentina R. / Fotolia

Men's susceptibility to serious health conditions may be influenced by low exposure to testosterone in the womb, new research suggests.

Related Articles


A study has revealed how men's testosterone levels may be determined before they are born.

Understanding why some men have less of the hormone than others is important because testosterone is crucial for life-long health. Low levels of the hormone have been linked to obesity, diabetes and heart disease.

Researchers have shown that the cells responsible for producing testosterone in adults -- known as Leydig cells -- are derived from a specific population of stem cells found in the testes.

The team found evidence of these stem cells in the developing testes of babies, rats, mice and marmosets in the womb.

Leydig cells do not develop until puberty but the team showed that their function is impaired if their stem cell forefathers are exposed to reduced levels of testosterone in the womb.

The study is the first to provide evidence of how events in the womb could influence male health in later life. It was led by scientists from the Medical Research Council (MRC) Centre for Reproductive Health at the University of Edinburgh.

Professor Richard Sharpe said: "There is increasing evidence that a mother's diet, lifestyle and exposure to drugs and chemicals can have a significant impact on testosterone levels in the womb. We need a better grasp of these factors so that we can give reliable advice to pregnant women to protect the health of her unborn child."


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. K. R. Kilcoyne, L. B. Smith, N. Atanassova, S. Macpherson, C. McKinnell, S. van den Driesche, M. S. Jobling, T. J. G. Chambers, K. De Gendt, G. Verhoeven, L. O'Hara, S. Platts, L. Renato de Franca, N. L. M. Lara, R. A. Anderson, R. M. Sharpe. Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1320735111

Cite This Page:

University of Edinburgh. "Male health linked to testosterone exposure in womb, study finds." ScienceDaily. ScienceDaily, 22 April 2014. <www.sciencedaily.com/releases/2014/04/140422113439.htm>.
University of Edinburgh. (2014, April 22). Male health linked to testosterone exposure in womb, study finds. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2014/04/140422113439.htm
University of Edinburgh. "Male health linked to testosterone exposure in womb, study finds." ScienceDaily. www.sciencedaily.com/releases/2014/04/140422113439.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins