Featured Research

from universities, journals, and other organizations

Study supports safety of antimicrobial peptide-coated contact lenses

Date:
April 24, 2014
Source:
Wolters Kluwer Health: Lippincott Williams & Wilkins
Summary:
Contact lenses coated with an antimicrobial peptide could help to lower the risk of contact lens-related infections, reports a study. Studies in animals and now humans support the biocompatibility and safety of lenses coated with the antimicrobial peptide melimine. The authors write, "[T]his study has shown that melimine coated contact lenses can be safely worn by humans without any major side effects."

Contact lenses coated with an antimicrobial peptide could help to lower the risk of contact lens-related infections, reports a study in Optometry and Vision Science, official journal of the American Academy of Optometry.The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Related Articles


Studies in animals and now humans support the biocompatibility and safety of lenses coated with the antimicrobial peptide melimine, according to the new research by Debarun Dutta, B.Optom, of The University of New South Wales, Sydney, and colleagues. They write, "[T]his study has shown that melimine coated contact lenses can be safely worn by humans without any major side effects."

Synthetic Coating Designed to Mimic Natural Infection-Fighting Peptides

The researchers performed a series of experiments to evaluate the safety of contact lenses coated with melimine, designed to reduce the risk of inflammation and infections. Melimine is not an antibiotic -- rather, it is a "cationic peptide" with broad-spectrum antimicrobial activity.

"Antimicrobial peptides are small peptides and part of the innate immune system of all multicellular organisms with the native ability to inhibit microbial growth," Dr. Dutta and colleagues explain. Melimine is among the first antimicrobial peptides to be tested for clinical use. The study used conventional disposable contact lenses to which melimine was molecularly (covalently) bonded.

Studies in rabbits supported the safety of melimine-coated contact lenses for up to three weeks. There were no signs of toxic effects on the eye, either in terms of inflammation/infection or on the cellular level.

In a subsequent study, human volunteers wore melimine-coated or conventional contact lenses for one day. The coated and uncoated lenses had similar characteristics, including wettability, surface deposits, lens fitting on the center of the eye, lens movement and tightness, and coverage of the cornea. Importantly, there were no differences in redness of the eye -- an early sign of irritation or inflammation.

No Signs of Safety Problems with Melimine-Coated Lenses in Human Eye

The only significant difference was increased staining of the cornea (the clear outer layer of the eye) caused by melimine-coated lenses. Comfort ratings were similar between the two lenses -- just one volunteer reported discomfort with the coated lenses.

No delayed reactions occurred after wearing melimine-coated lenses. The day after they were worn, the lenses were still active against Pseudomonas and Staphylococcus bacteria in culture.

Wearing contaminated contact lenses can cause redness and inflammation of the eye, leading to rare but potentially serious infections. "A contact lens with high antimicrobial activity may inhibit microbial adhesion and consequently reduce these…adverse events," Dr Dutta and coauthors write. Preliminary studies in animals have supported further research and development of contact lenses coated with melimine.

The new results add to previous data on the safety of melimine-coated lenses in animals, and provide initial evidence of their safety and comfort in humans. The lenses also show lasting antimicrobial activity. Dr. Dutta and colleagues add, "Whether melimine could reduce contact lens-related adverse events during wear, especially extended wear, requires more clinical trials."

"Practitioners and researchers are hoping to develop new ways to try to reduce rare corneal infections associated with contact lens wear," comments Anthony Adams, OD, PhD, Editor-in-Chief of Optometry and Vision Science. He notes that the melimine-coated contact lenses show broad-spectrum antimicrobial properties, and appear safe and effect against Pseudmonas and Staphylococcus bacteria -- some of the major "bad actors" causing corneal infections. Dr. Adams adds, "While the study is one of the earlier demonstrations, it does appear to be promising."


Story Source:

The above story is based on materials provided by Wolters Kluwer Health: Lippincott Williams & Wilkins. Note: Materials may be edited for content and length.


Journal Reference:

  1. Debarun Dutta, Jerome Ozkan, Mark D. P. Willcox. Biocompatibility of Antimicrobial Melimine Lenses. Optometry and Vision Science, 2014; 91 (5): 570 DOI: 10.1097/OPX.0000000000000232

Cite This Page:

Wolters Kluwer Health: Lippincott Williams & Wilkins. "Study supports safety of antimicrobial peptide-coated contact lenses." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424112744.htm>.
Wolters Kluwer Health: Lippincott Williams & Wilkins. (2014, April 24). Study supports safety of antimicrobial peptide-coated contact lenses. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2014/04/140424112744.htm
Wolters Kluwer Health: Lippincott Williams & Wilkins. "Study supports safety of antimicrobial peptide-coated contact lenses." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424112744.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins