Featured Research

from universities, journals, and other organizations

Study supports safety of antimicrobial peptide-coated contact lenses

Date:
April 24, 2014
Source:
Wolters Kluwer Health: Lippincott Williams & Wilkins
Summary:
Contact lenses coated with an antimicrobial peptide could help to lower the risk of contact lens-related infections, reports a study. Studies in animals and now humans support the biocompatibility and safety of lenses coated with the antimicrobial peptide melimine. The authors write, "[T]his study has shown that melimine coated contact lenses can be safely worn by humans without any major side effects."

Contact lenses coated with an antimicrobial peptide could help to lower the risk of contact lens-related infections, reports a study in Optometry and Vision Science, official journal of the American Academy of Optometry.The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

Studies in animals and now humans support the biocompatibility and safety of lenses coated with the antimicrobial peptide melimine, according to the new research by Debarun Dutta, B.Optom, of The University of New South Wales, Sydney, and colleagues. They write, "[T]his study has shown that melimine coated contact lenses can be safely worn by humans without any major side effects."

Synthetic Coating Designed to Mimic Natural Infection-Fighting Peptides

The researchers performed a series of experiments to evaluate the safety of contact lenses coated with melimine, designed to reduce the risk of inflammation and infections. Melimine is not an antibiotic -- rather, it is a "cationic peptide" with broad-spectrum antimicrobial activity.

"Antimicrobial peptides are small peptides and part of the innate immune system of all multicellular organisms with the native ability to inhibit microbial growth," Dr. Dutta and colleagues explain. Melimine is among the first antimicrobial peptides to be tested for clinical use. The study used conventional disposable contact lenses to which melimine was molecularly (covalently) bonded.

Studies in rabbits supported the safety of melimine-coated contact lenses for up to three weeks. There were no signs of toxic effects on the eye, either in terms of inflammation/infection or on the cellular level.

In a subsequent study, human volunteers wore melimine-coated or conventional contact lenses for one day. The coated and uncoated lenses had similar characteristics, including wettability, surface deposits, lens fitting on the center of the eye, lens movement and tightness, and coverage of the cornea. Importantly, there were no differences in redness of the eye -- an early sign of irritation or inflammation.

No Signs of Safety Problems with Melimine-Coated Lenses in Human Eye

The only significant difference was increased staining of the cornea (the clear outer layer of the eye) caused by melimine-coated lenses. Comfort ratings were similar between the two lenses -- just one volunteer reported discomfort with the coated lenses.

No delayed reactions occurred after wearing melimine-coated lenses. The day after they were worn, the lenses were still active against Pseudomonas and Staphylococcus bacteria in culture.

Wearing contaminated contact lenses can cause redness and inflammation of the eye, leading to rare but potentially serious infections. "A contact lens with high antimicrobial activity may inhibit microbial adhesion and consequently reduce these…adverse events," Dr Dutta and coauthors write. Preliminary studies in animals have supported further research and development of contact lenses coated with melimine.

The new results add to previous data on the safety of melimine-coated lenses in animals, and provide initial evidence of their safety and comfort in humans. The lenses also show lasting antimicrobial activity. Dr. Dutta and colleagues add, "Whether melimine could reduce contact lens-related adverse events during wear, especially extended wear, requires more clinical trials."

"Practitioners and researchers are hoping to develop new ways to try to reduce rare corneal infections associated with contact lens wear," comments Anthony Adams, OD, PhD, Editor-in-Chief of Optometry and Vision Science. He notes that the melimine-coated contact lenses show broad-spectrum antimicrobial properties, and appear safe and effect against Pseudmonas and Staphylococcus bacteria -- some of the major "bad actors" causing corneal infections. Dr. Adams adds, "While the study is one of the earlier demonstrations, it does appear to be promising."


Story Source:

The above story is based on materials provided by Wolters Kluwer Health: Lippincott Williams & Wilkins. Note: Materials may be edited for content and length.


Journal Reference:

  1. Debarun Dutta, Jerome Ozkan, Mark D. P. Willcox. Biocompatibility of Antimicrobial Melimine Lenses. Optometry and Vision Science, 2014; 91 (5): 570 DOI: 10.1097/OPX.0000000000000232

Cite This Page:

Wolters Kluwer Health: Lippincott Williams & Wilkins. "Study supports safety of antimicrobial peptide-coated contact lenses." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424112744.htm>.
Wolters Kluwer Health: Lippincott Williams & Wilkins. (2014, April 24). Study supports safety of antimicrobial peptide-coated contact lenses. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/04/140424112744.htm
Wolters Kluwer Health: Lippincott Williams & Wilkins. "Study supports safety of antimicrobial peptide-coated contact lenses." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424112744.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins