Featured Research

from universities, journals, and other organizations

Higher muscle mass linked with better physical function, quality of life in dialysis patients

Date:
April 24, 2014
Source:
American Society of Nephrology (ASN)
Summary:
Dialysis patients with higher BMI, waist circumference, and abdominal fat measures had poorer scores on a 6-minute walking test, according to a new study. Patients with more muscle mass had better scores on the walking test as well as better scores on physical and mental health questionnaires. The findings may help explain the "obesity paradox" associated with dialysis patients, which relates to the prolonged survival sometimes seen in obese patients compared with normal-weight patients.

Dialysis patients with more muscle mass had better scores on a 6-minute walking test as well as better scores on physical and mental health questionnaires in a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The findings suggest that physical activity that builds muscle mass may help improve the health and quality of life of dialysis patients.

Physical functional ability is often significantly impaired in patients on maintenance hemodialysis. Srinivasan Beddhu, MD (University of Utah), Macy Martinson, MD (University of Utah), T. Alp Ikizler (Vanderbilt University), and their colleagues wondered whether modifiable factors such as body size and body composition could influence dialysis patients' physical function and quality of life.

To investigate, the researchers assessed 105 maintenance dialysis patients' body mass index (BMI), waist circumference, and measurements of mid-thigh muscle area and intra-abdominal fat area. They also tested how far patients could walk in 6 minutes, and they examined other measures of physical and mental health through questionnaires. Assessments were made at the start of the study, after 6 months, and after 12 months.

The investigators found that higher BMI levels at the start of the study were linked with shorter 6-minute walking distances measured at both at the start of the study and at later time points. Results were similar for waist circumference and intra-abdominal fat. On the other hand, higher levels of mid-thigh muscle -- which indicates higher muscle mass -- were linked with longer 6-minute walking distances. After adjusting for BMI, increases in mid-thigh muscle were also strongly linked with higher physical and mental health scores at the start of the study, but only weakly so at later time points.

"Because this study shows that higher muscle mass is associated with better physical function and quality of life in dialysis patients, interventions such as increased physical activity that decrease fat mass and increase muscle mass are likely to improve physical function, quality of life, and survival in dialysis patients," said Dr. Beddhu. "Such interventions need to be tested in clinical trials."

The findings may help explain the "obesity paradox" associated with dialysis patients, which relates to the prolonged survival sometimes seen in obese patients compared with normal-weight patients. "The obesity paradox has been interpreted in earlier studies as fat is good. Some have even argued that weight loss should be discouraged in dialysis patients," said Dr. Beddhu. "But the situation is more nuanced. This study provides a better understanding of the role of body composition in dialysis patients."


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Martinson, T. A. Ikizler, G. Morrell, G. Wei, N. Almeida, R. L. Marcus, R. Filipowicz, T. H. Greene, S. Beddhu. Associations of Body Size and Body Composition with Functional Ability and Quality of Life in Hemodialysis Patients. Clinical Journal of the American Society of Nephrology, 2014; DOI: 10.2215/CJN.09200913

Cite This Page:

American Society of Nephrology (ASN). "Higher muscle mass linked with better physical function, quality of life in dialysis patients." ScienceDaily. ScienceDaily, 24 April 2014. <www.sciencedaily.com/releases/2014/04/140424190401.htm>.
American Society of Nephrology (ASN). (2014, April 24). Higher muscle mass linked with better physical function, quality of life in dialysis patients. ScienceDaily. Retrieved September 19, 2014 from www.sciencedaily.com/releases/2014/04/140424190401.htm
American Society of Nephrology (ASN). "Higher muscle mass linked with better physical function, quality of life in dialysis patients." ScienceDaily. www.sciencedaily.com/releases/2014/04/140424190401.htm (accessed September 19, 2014).

Share This



More Health & Medicine News

Friday, September 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com
The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins