Featured Research

from universities, journals, and other organizations

Monkey model of hantavirus disease established

Date:
April 28, 2014
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
An animal model of human hantavirus pulmonary syndrome has been developed for rhesus macaques, an advance that may lead to treatments, vaccines and improved methods of diagnosing the disease. People become infected with hantaviruses by inhaling virus from the urine, droppings or saliva of infected rodents. This infection can progress to HPS, a severe respiratory disease that was first identified in 1993 in the southwestern United States. HPS attained global attention in the summer of 2012 when physicians diagnosed 10 cases -- three of them fatal -- in Yosemite National Park in California.

A sin nombre virus particle emerges from a cell.
Credit: National Institute of Allergy and Infectious Diseases

National Institutes of Health (NIH) researchers have developed an animal model of human hantavirus pulmonary syndrome (HPS) in rhesus macaques, an advance that may lead to treatments, vaccines and improved methods of diagnosing the disease. The study, conducted by researchers at NIH's National Institute of Allergy and Infectious Diseases (NIAID), is published in the Proceedings of the National Academy of Sciences.

Related Articles


People become infected with hantaviruses by inhaling virus from the urine, droppings or saliva of infected rodents. This infection can progress to HPS, a severe respiratory disease that was first identified in 1993 in the southwestern United States. HPS attained global attention in the summer of 2012 when physicians diagnosed 10 cases -- three of them fatal -- in Yosemite National Park in California. The primary HPS agents are Sin Nombre virus in North America and Andes virus in South America. Since 1993, the Centers for Disease Control and Prevention has reported approximately 600 HPS cases, including 200 deaths, in the United States; case numbers for South America are not available.

In their study, NIAID scientists infected healthy deer mice with Sin Nombre virus obtained from descendants of wild deer mice. The researchers then exposed 10 rhesus macaques to the virus derived from the newly infected deer mice. Nine monkeys became infected and seven developed severe disease. In the diseased macaques, researchers observed how and where the virus established infection, evaded the immune system and caused pneumonia. Of note, they report that, similar to hantavirus infection in people, the virus in the monkey model triggers a life-threatening immune response nearly two weeks after infection. NIAID researchers aim to identify biological markers during that initial timeframe that may be useful for early diagnosis.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. Safronetz, J. Prescott, F. Feldmann, E. Haddock, R. Rosenke, A. Okumura, D. Brining, E. Dahlstrom, S. F. Porcella, H. Ebihara, D. P. Scott, B. Hjelle, H. Feldmann. Pathophysiology of hantavirus pulmonary syndrome in rhesus macaques. Proceedings of the National Academy of Sciences, 2014; DOI: 10.1073/pnas.1401998111

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Monkey model of hantavirus disease established." ScienceDaily. ScienceDaily, 28 April 2014. <www.sciencedaily.com/releases/2014/04/140428164113.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2014, April 28). Monkey model of hantavirus disease established. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/04/140428164113.htm
NIH/National Institute of Allergy and Infectious Diseases. "Monkey model of hantavirus disease established." ScienceDaily. www.sciencedaily.com/releases/2014/04/140428164113.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins